2024 淋巴瘤研究基金会关于 CLL 或 SLL 治疗选择和排序研讨会的共识建议。

IF 7.4 1区 医学 Q1 HEMATOLOGY
Jacob D Soumerai, Jacqueline Claudia Barrientos, Inhye E Ahn, Catherine C Coombs, Douglas E Gladstone, Marc S Hoffmann, Adam S Kittai, Ryan W Jacobs, Andrew Lipsky, Krish Patel, Joanna M Rhodes, Alan P Skarbnik, Meghan C Thompson, Daniel A Ermann, Patrick K Reville, Harsh R Shah, Jennifer R Brown, Deborah M Stephens
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引用次数: 0

摘要

在过去十年中,慢性淋巴细胞白血病或小淋巴细胞淋巴瘤(CLL/SLL)患者的治疗建议已从传统的化学免疫疗法转向靶向疗法。市场上出现了多种新疗法,但在许多情况下,由于缺乏随机临床试验数据,为每位患者选择最佳治疗方法变得十分困难。此外,在美国,许多患者仍在接受化学免疫疗法,这表明指南与实际操作之间存在差距。淋巴瘤研究基金会召开了一次由美国 CLL/SLL 专家组成的研讨会,为美国 CLL/SLL 患者的疗法选择和排序制定共识建议。在此,我们将这些建议汇编成册,作为护理 CLL/SLL 患者的治疗提供者的实用临床指南,通过对美国 CLL/SLL 专家小组在实际环境中如何护理患者进行细致入微的讨论,对现有指南进行补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Consensus Recommendations from the 2024 Lymphoma Research Foundation Workshop on Treatment Selection and Sequencing in CLL or SLL.

Over the past decade, treatment recommendations for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) have shifted from traditional chemoimmunotherapy to targeted therapies. Multiple new therapies are commercially available, and in many cases a lack of randomized clinical trial data makes selection of the optimal treatment for each patient challenging. Additionally, many patients continue to receive chemoimmunotherapy in the US, suggesting a gap between guidelines and real-world practice. The Lymphoma Research Foundation convened a workshop comprised of a panel of CLL/SLL experts in the US to develop consensus recommendations for selection and sequencing of therapies for patients with CLL/SLL in the US. Herein, the recommendations are compiled for use as a practical clinical guide for treating providers caring for patients with CLL/SLL, which complement existing guidelines by providing a nuanced discussion relating how our panel of CLL/SLL experts in the US care for patients in a real-world environment.

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来源期刊
Blood advances
Blood advances Medicine-Hematology
CiteScore
12.70
自引率
2.70%
发文量
840
期刊介绍: Blood Advances, a semimonthly medical journal published by the American Society of Hematology, marks the first addition to the Blood family in 70 years. This peer-reviewed, online-only, open-access journal was launched under the leadership of founding editor-in-chief Robert Negrin, MD, from Stanford University Medical Center in Stanford, CA, with its inaugural issue released on November 29, 2016. Blood Advances serves as an international platform for original articles detailing basic laboratory, translational, and clinical investigations in hematology. The journal comprehensively covers all aspects of hematology, including disorders of leukocytes (both benign and malignant), erythrocytes, platelets, hemostatic mechanisms, vascular biology, immunology, and hematologic oncology. Each article undergoes a rigorous peer-review process, with selection based on the originality of the findings, the high quality of the work presented, and the clarity of the presentation.
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