2022 年 185 个国家按亚型、年龄和性别分列的全球白血病模式

IF 12.8 1区 医学 Q1 HEMATOLOGY
Dagrun S. Daltveit, Eileen Morgan, Murielle Colombet, Eva Steliarova-Foucher, Karima Bendahhou, Rafael Marcos-Gragera, Zheng Rongshou, Alexandra Smith, Hui Wei, Isabelle Soerjomataram
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引用次数: 0

摘要

2022 年,白血病成为仅次于非霍奇金淋巴瘤的全球第二大常见血液恶性肿瘤。然而,目前还没有按亚型对全球白血病发病率的最新估计。我们利用五大洲癌症发病率数据库中的数据,结合 2022 年全球白血病数据库(GLOBOCAN)对 185 个国家的白血病发病率估计,按国家、世界地区和人类发展指数对不同白血病亚型的发病率进行了估计。我们估算了儿童(0-19 岁)和成人(20 岁以上)每 10 万人的性别年龄标准化发病率 (ASR)。在成人中,全球最常见的白血病是急性髓细胞白血病(男性:38%,ASR = 3-1;女性:43%,ASR = 2-4),其次是慢性粒细胞白血病(男性:28%,ASR = 2-2;女性:24%,ASR = 1-3)。在人类发展指数很高的国家中,男性 CLL 的 ASR 高于 AML(分别为 5-2 和 4-3),而女性 CLL 的 ASR 与 AML 相似(分别为 2-9 和 3-0)。在儿童中,最常见的白血病是 ALL(男孩:70%,ASR = 2-4;女孩:68%,ASR = 1-8),其次是 AML(男孩:22%,ASR = 0-76;女孩:25%,ASR = 0-65)。世界各分区域的 ALL 比例各不相同,男孩从 57% 到 78%,女孩从 49% 到 80%。我们的研究结果表明,成人和儿童的白血病亚型具有明显的地理模式。需要进一步研究解释这些差异的根本原因,以支持癌症预防控制策略,规划国家医疗保健需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Global patterns of leukemia by subtype, age, and sex in 185 countries in 2022

Global patterns of leukemia by subtype, age, and sex in 185 countries in 2022

In 2022, leukemia ranked as the second most common hematological malignancy after non-Hodgkin lymphoma worldwide. However, updated global estimates of leukemia incidence by subtype are unavailable. We estimated leukemia incidences for different leukemia subtypes by country, world region, and human developmental index using data from the Cancer Incidence in Five Continents databases combined with the GLOBOCAN 2022 estimates of leukemia in 185 countries. We estimated sex-specific age-standardized rates (ASRs) per 100 000 for children (0–19 years) and adults (20+ years). In adults, the most common leukemia worldwide was AML (males: 38%, ASR = 3·1; females: 43%, ASR = 2·4), followed by CLL (males: 28%, ASR = 2·2; females: 24%, ASR = 1·3). In very high HDI countries, the ASR of CLL was higher than the ASR of AML among males (5·2 versus 4·3, respectively) and similar among females (2·9 and 3·0, respectively). In children, the most common leukemia was ALL (boys: 70%, ASR = 2·4; girls: 68%, ASR = 1·8) followed by AML (boys: 22%, ASR = 0·76; girls: 25%, ASR = 0·65). ALL proportions varied across world sub-regions from 57 to 78% among boys, and from 49 to 80% among girls. Our findings suggest clear geographical patterns of leukemia subtypes in adults and children. Further research into underlying causes that explain these variations is needed to support cancer control strategies for prevention and plan national healthcare needs.

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来源期刊
Leukemia
Leukemia 医学-血液学
CiteScore
18.10
自引率
3.50%
发文量
270
审稿时长
3-6 weeks
期刊介绍: Title: Leukemia Journal Overview: Publishes high-quality, peer-reviewed research Covers all aspects of research and treatment of leukemia and allied diseases Includes studies of normal hemopoiesis due to comparative relevance Topics of Interest: Oncogenes Growth factors Stem cells Leukemia genomics Cell cycle Signal transduction Molecular targets for therapy And more Content Types: Original research articles Reviews Letters Correspondence Comments elaborating on significant advances and covering topical issues
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