镍催化的电化学还原共轭α、β-不饱和酮的对映体选择性烯化反应

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2024-11-20 DOI:10.1039/d4sc06891b

Siriphong Somprasong, Syuzanna R. Harutyunyan, Bin Wan

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引用次数: 0

摘要

催化电化学不对称催化开始成为合成手性化合物的一种有前途的策略。在此，我们报告了镍催化的不对称电化学还原共轭加成法，在不分裂电池中将烯基溴化物/芳基碘化物与 α,β-不饱和酮进行加成，得到的加成产物具有高产率和优异的对映选择性（产率高达 96%，ee 为 96%）。

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Enantioselective Nickel-Catalyzed Electrochemical Reductive Conjugate Alkenylation of α,β-Unsaturated Ketones

Catalytic electrochemical asymmetric catalysis starting to emerg as a promising strategy for the synthesis of chiral compounds. Herein, we report an asymmetric electrochemical nickel-catalysed reductive conjugate addition of alkenyl bromides/aryl iodides to α,β-unsaturated ketones in an undivided cell, leading to the addition products with high yields and excellent enantioselectivities (up to 96% yield and 96% ee).

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.