光诱导的乌尔曼型交叉偶联反应：机理认识与新挑战

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-11-20 DOI:10.1039/d4qo01814a

Ahmed Th Abdulghaffar, Hao-Long Zhang, Qiankun Zhang, Qian Tong, Ruirui Tian, Hao Xu, Jiawei Yang, Yuanqing Xu

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引用次数: 0

摘要

光诱导乌尔曼型交叉偶联反应已成为有机合成领域的一大进步，为在更温和的光驱动条件下形成 C-C 和 C- 异原子键提供了一种有效的方法。这些反应利用铜催化，通过提高反应效率和促进更可持续的工艺流程，与传统的热方法相比具有相当大的优势。本综述对近期的机理发展进行了评估，重点关注非链单电子转移（SET）机理，该机理是这些转化成功的关键。讨论包括对同质和异质催化系统的最新概述，探讨其实际应用和固有局限性。此外，本综述还指出了一些关键挑战，如催化剂稳定性、可扩展性以及激活芳基氯化物等低活性底物的难度。针对这些局限性，我们提出了旨在克服这些障碍的未来研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photoinduced Ullmann-Type Cross-Coupling Reactions: Mechanistic Insights and Emerging Challenges

Photoinduced Ullmann-type cross-coupling reactions have become a significant advancement in organic synthesis, providing an efficient means to form C–C and C–heteroatom bonds under milder, light-driven conditions. Utilizing copper catalysis, these reactions present considerable benefits over traditional thermal methods by improving reaction efficiency and promoting more sustainable processes. This review offers an evaluation of recent mechanistic developments, with a focus on the nonchain single-electron transfer (SET) mechanism, which is central to the success of these transformations. The discussion includes an up-to-date overview of both homogeneous and heterogeneous catalytic systems, addressing their practical applications and inherent limitations. In addition, this review identifies key challenges, such as catalyst stability, scalability, and the difficulty of activating less reactive substrates like aryl chlorides. To address these limitations, we propose future research directions aimed at overcoming these obstacles.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.