用于质子治疗剂量测定的 3D 打印轨迹端探测器的原理验证。

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2024-11-18 DOI:10.1002/mp.17515
Vicky Bietenbeck, Claus Maximilian Bäcker, Jörg Wulff, Beate Timmermann, Christian Bäumer
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引用次数: 0

摘要

背景:粒子治疗(PT)的剂量测定设备成本高昂。目前缺乏适用于体内剂量测定的多功能组织等效探测器。法拉第杯(FC)型探测器对停止质子(即轨迹末端(TE))敏感。由于它们可以承受高剂量率,因此在 PT 领域得到了复兴。由于其功能原理简单,FC 型探测器的生产可受益于传感器快速成型技术的蓬勃发展。本研究旨在建造一个集成的单通道(SC)FC,用于替代传统的FC和一个2 × 2 (2次)FC元件阵列,表明空间分辨率探测器的可行性:FC样品是用双挤出机3D打印机用聚乳酸丝制作的,探测器的导电部分含有石墨。生产过程中对材料和打印温度进行了优化。样品通过电气测试和非破坏性 3D X 射线成像进行表征。在临床 PT 机上进行了光束测试:结果:打印出了用于质子场的可运行 FC 型探测器。SC FC 检测到的电荷与传统 FC 检测到的电荷基本一致。一次运行就制造出了一个 2 × 2 $2\times 2$ 的 FC 阵列。单个 FC 元件的响应与机器输出之间存在线性关系:三维打印是生产用于 PT 的低成本、组织等效的 FC 型探测器的可行方法。它们有可能被用作拟人模型中的 TE 探测器。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Proof-of-principle of 3D-printed track-end detectors for dosimetry in proton therapy

Proof-of-principle of 3D-printed track-end detectors for dosimetry in proton therapy

Background

Dosimetric equipment in particle therapy (PT) is associated with high costs. There is a lack of versatile, tissue-equivalent detectors suitable for in-vivo dosimetry. Faraday-cup (FC) type detectors are sensitive to stopped protons, that is, to track-ends (TEs). They experience a renaissance in PT as they can cope with high dose rates. Owing to their simple functional principle, production of FC could benefit from the dynamic technological developments in additive manufacturing of sensors.

Purpose

To build FC-type detectors for PT by standard 3D-printing. This study seeks to build an integrating, single-channel (SC) FC for replacement of a traditional FC and a 2 × 2 $2\times 2$ array of FC elements indicating the feasibility of a spatially resolving detector.

Methods

Samples of FCs were produced with a dual-extruder 3D-printer with polylactic-acid filaments, which contained graphite in the conductive parts of the detector. Production was optimized in terms of materials and printing temperature. Samples were characterized by electrical tests and non-destructive 3D x-ray imaging. Beam tests were conducted at a clinical PT machine.

Results

Operational FC-type detectors for proton fields were printed. The detected charge of the SC FC corresponded qualitatively to the one of a traditional FC. A 2 × 2 $2\times 2$ FC array was fabricated in a single run. There was a linear relationship between the response of the individual FC elements and the machine output.

Conclusions

3D-printing is a viable method for producing low-cost, tissue-equivalent, FC-type detectors for PT. They could potentially be used as TE detectors in anthropomorphic phantoms.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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