血小板活化因子：改善癌症免疫疗法的潜在治疗靶点。

IF 6.6 2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Molecular Oncology Pub Date : 2024-11-19 DOI:10.1002/1878-0261.13758

Qi Yan, Hemn Mohammadpour

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引用次数: 0

摘要

肿瘤微环境（TME）通过支持髓源性抑制细胞（MDSCs）的分化和增殖来促进癌症的进展，而髓源性抑制细胞在抑制免疫反应和促进肿瘤生长方面起着至关重要的作用。Dahal 等人的最新研究结果表明，血小板活化因子（PAF）是一种在 TME 中升高的脂质介质，有助于中性粒细胞分化为免疫抑制性中性粒细胞。他们的研究表明，抑制 PAF 信号传导可减少 MDSC 介导的免疫抑制，从而增强细胞毒性 T 细胞的活性。这种方法可能会改善癌症免疫疗法的疗效，尤其是在与检查点阻断疗法相结合时，这为治疗方法的开发提供了一个前景广阔的途径。

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Platelet-activating factor: a potential therapeutic target to improve cancer immunotherapy.

The tumor microenvironment (TME) fosters cancer progression by supporting the differentiation and proliferation of myeloid-derived suppressor cells (MDSCs), which play a critical role in suppressing immune responses and facilitating tumor growth. Recent findings by Dahal et al. reveal that platelet-activating factor (PAF), a lipid mediator elevated in the TME, contributes to the differentiation of neutrophils into immunosuppressive neutrophils. They showed that inhibiting PAF signaling reduces MDSC-mediated immunosuppression, thereby enhancing cytotoxic T-cell activity. This approach may improve cancer immunotherapy outcomes, particularly when combined with checkpoint blockade therapies, suggesting a promising avenue for therapeutic development.

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来源期刊

Molecular Oncology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

11.80

自引率

1.50%

发文量

203

审稿时长

10 weeks

期刊介绍： Molecular Oncology highlights new discoveries, approaches, and technical developments, in basic, clinical and discovery-driven translational cancer research. It publishes research articles, reviews (by invitation only), and timely science policy articles. The journal is now fully Open Access with all articles published over the past 10 years freely available.