了解乳腺癌的遗传结构：全蛋白质组关联研究如何做出贡献？

IF 6.4 1区医学 Q1 ONCOLOGY

British Journal of Cancer Pub Date : 2024-11-18 DOI:10.1038/s41416-024-02905-2

Yijia Sun, Dezheng Huo

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引用次数: 0

摘要

蛋白质组关联研究（PWAS）解决了转录后修饰的空白，这是以前的基因组和转录组关联研究无法捕捉到的。Zhao和他的同事进行了第一个基于乳腺组织的PWAS，并确定了与乳腺癌风险相关的蛋白质，为蛋白质表达在乳腺癌发展中的作用提供了见解。

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Understanding genetic architecture of breast cancer: how can proteome-wide association studies contribute?

Proteome-wide association studies (PWAS) address gaps in post-transcriptional modifications that previous genome- and transcriptome-wide association studies could not capture. Zhao and colleagues conducted the first breast tissue-based PWAS and identified proteins associated with breast cancer risk, providing insights into the role of protein expression in breast cancer development.

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来源期刊

British Journal of Cancer 医学-肿瘤学

CiteScore

15.10

自引率

1.10%

发文量

383

审稿时长

6 months

期刊介绍： The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.