开发抗菌剂:通过氧杂蒽染料的羟基连接卟啉和玫瑰红分子的混合荧光团的设计和抗菌活性。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI:10.1016/j.bioorg.2024.107960
G Mamardashvili, E Kaigorodova, N Solomonova, N Mamardashvili
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引用次数: 0

摘要

研究人员获得了 Sn(IV)-四(4-磺酸苯基)卟啉(SnP)与玫瑰红(RB)的轴向配合物,其中 RB 轴向结合是通过氧杂蒽染料的羟基实现的[SnP(RB)2]。研究了 SnP(RB)2 在添加了表面活性剂十六烷基氯化吡啶(CPC)和ε-聚-l-赖氨酸(EPL)的水介质中的发光特性(荧光和室温下产生单线态氧的能力)。研究发现,介质的性质(不同浓度的表面活性剂添加剂)决定了光诱导能量从混合荧光团(HF)的 RB 片段转移到 SnP 片段的有效性。已经证实,HF 在 D2O 和 D2O-胶束介质中产生单线态氧的能力高于其组成片段。测定并分析了 HF 对两种微生物[铜绿假单胞菌(P. aeruginosa)和金黄色葡萄球菌(S. aureus)]的暗抗菌活性和光动力抗菌活性。结果表明,高频的抗菌活性取决于细菌的性质、胶束环境和辐射剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Towards antimicrobial agents: Design and antibacterial activity of a hybrid fluorophore where porphyrin and Rose Bengal moieties are linked through the hydroxyl group of a xanthene dye.

The axial complex of Sn(IV)-tetra(4-sulfophenyl)porphyrin (SnP) with Rose Bengal (RB) was obtained where RB axial binding is realized through the hydroxyl groups of the xanthene dye [SnP(RB)2]. The luminescent properties of the SnP(RB)2 (fluorescence and ability to generate singlet oxygen at room temperature) in aqueous media with additives of surfactant cetylpyridinium chloride (CPC) and ε-poly-l-lysine (EPL) were studied. It was found that nature of the medium (surfactant additives of different concentrations) determines the effectiveness of the photoinduced energy transfer from the RB fragment to the SnP fragment of the hybrid fluorophore (HF). It has been established that the ability of the HF to generate singlet oxygen in D2O and D2O-micellar media is higher than that of its constituent fragments. The dark and photodynamic antibacterial activity of the HF against two microorganisms [Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus)] was determined and analyzed. It was shown how the antibacterial activity of the HF depends on the nature of the bacteria, the micellar environment and radiation dose.

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来源期刊
Bioorganic Chemistry
Bioorganic Chemistry 生物-生化与分子生物学
CiteScore
9.70
自引率
3.90%
发文量
679
审稿时长
31 days
期刊介绍: Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry. For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature. The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.
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