酯酶反应纳米粒子（ERN）：药物/基因递送的靶向方法探索

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2024-11-14 DOI:10.1016/j.bmc.2024.118001

Ashok Kumar Madikonda , Amritha Ajayakumar , Sudeena Nadendla , Janardhan Banothu , Venkanna Muripiti

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引用次数: 0

摘要

目前正在开发纳米颗粒，以利用增强渗透性和滞留（EPR）效应等优势，加强对癌症肿瘤的药物输送。然而，传统的纳米颗粒往往面临着对癌细胞特异性低的挑战，导致给药效率低下和不必要的副作用。酯酶响应型纳米粒子能在酯酶活性的影响下在肿瘤部位释放治疗载荷，因此能最大程度地靶向治疗肿瘤细胞。本综述探讨了酯酶反应纳米粒子在药物和基因递送中的作用，研究了酯酶原药疗法，并讨论了前列腺特异性膜抗原（PSMA）靶向酯酶反应纳米粒子在前列腺癌治疗中的应用。此外，我们还回顾了酯酶反应纳米粒子在加强药物和基因递送方面的当前研究进展和未来潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Esterase-responsive nanoparticles (ERN): A targeted approach for drug/gene delivery exploits

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Esterase-responsive nanoparticles (ERN): A targeted approach for drug/gene delivery exploits

Nanoparticles are being developed to enhance drug delivery to cancer tumors, leveraging advantages such as the enhanced permeability and retention (EPR) effect. However, traditional nanoparticles often face challenges with low specificity for cancer cells, leading to inefficient delivery and unwanted side effects. Esterase-responsive nanoparticles offer a maximum targeted approach to tumor cells because they release their therapeutic payload at the tumor site under the influence of esterase activity. This review explores the role of esterase-responsive nanoparticles in drug and gene delivery, examines esterase prodrug therapy, and discusses prostate-specific membrane antigen (PSMA) targets esterase-responsive nanoparticles in prostate cancer treatment. Additionally, we reviewed the current research progress and future potential of esterase-responsive nanoparticles in enhancing drug and gene delivery.

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.