Huanyu Qian, Lixia Wang, Jie Xu, Tao He, Jian Liu, Zhijun Duan
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引用次数: 0
摘要
背景：胃食管反流病（GERD）与慢性阻塞性肺疾病（COPD）之间存在明显的相关性。然而，人们对反流性食管炎（RE）与慢性阻塞性肺疾病之间关系的确切性质仍不甚了解。在这项研究中，我们调查了反流性食管炎与肺功能之间的联系，重点是阐明反流性食管炎与慢性阻塞性肺疾病在肺功能方面的相互作用：研究队列包括 2021 年 4 月至 2023 年 10 月期间在大连医科大学附属第一医院接受肺功能测试（PFT）前后一年内接受肺功能测试和内窥镜检查的患者。系统记录了每位参与者的主要人口统计学变量，包括年龄、性别、体重指数（BMI）以及 PFT 和内镜检查结果。统计评估采用 SPSS 统计 29.0 版，以 PResults 临界值为显著性判定标准：在慢性阻塞性肺病患者中，分为 RE 组和非 RE 组的人群在几项肺功能参数上存在明显差异，包括 1 秒用力呼气量（FEV1）、1 秒用力呼气量与用力肺活量之比（FEV1/FVC）、最大呼气中流量（MMEF75/25）和呼气储备量（ERV）。此外，在峰值呼气流量（PEF）方面也观察到了统计学上的显著差异。总体而言，RE 与慢性阻塞性肺病的严重程度没有关联，慢性阻塞性肺病的严重程度与 RE 之间也没有明显的相关性：结论：RE 被认为是导致无潜在呼吸系统疾病的人和被诊断为慢性阻塞性肺病的人肺功能减退的一个因素。然而，慢性阻塞性肺病的严重程度与 RE 的存在之间并不存在相互作用。
Association between reflux esophagitis and pulmonary function in patients with chronic obstructive pulmonary disease.
Background: A discernible correlation exists between gastroesophageal reflux disease (GERD) and chronic obstructive pulmonary disease (COPD). However, the precise nature of the association between reflux esophagitis (RE) and COPD remains inadequately understood. In this study, we investigated the link between RE and pulmonary function, with a specific emphasis on elucidating the interplay between RE and COPD regarding lung function.
Methods: The study cohort comprised patients who underwent both pulmonary function tests (PFTs) and endoscopic examinations within a one-year period preceding and following their PFTs at The First Affiliated Hospital of Dalian Medical University from April 2021 to October 2023. Key demographic variables including age, gender, body mass index (BMI), as well as results from PFTs and endoscopy, were systematically documented for each participant. Statistical evaluations were conducted utilizing SPSS Statistics version 29.0, with significance determined at a threshold of P<0.05.
Results: Among patients with COPD, there were notable distinctions between cohorts categorized into RE and non-RE groups concerning several pulmonary function parameters, including forced expiratory volume in 1 second (FEV1), the ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC), maximum mid-expiratory flow (MMEF75/25), and expiratory reserve volume (ERV). Furthermore, there were statistically significant disparities observed in peak expiratory flow (PEF). Overall, RE did not exhibit an association with COPD severity, and there was no notable correlation found between the COPD severity and RE.
Conclusions: RE has been identified as a factor contributing to diminished pulmonary function in both individuals without underlying respiratory conditions and those diagnosed with COPD. Nevertheless, an absence of interaction was observed between the severity of COPD and the presence of RE.
期刊介绍：
The Journal of Thoracic Disease (JTD, J Thorac Dis, pISSN: 2072-1439; eISSN: 2077-6624) was founded in Dec 2009, and indexed in PubMed in Dec 2011 and Science Citation Index SCI in Feb 2013. It is published quarterly (Dec 2009- Dec 2011), bimonthly (Jan 2012 - Dec 2013), monthly (Jan. 2014-) and openly distributed worldwide. JTD received its impact factor of 2.365 for the year 2016. JTD publishes manuscripts that describe new findings and provide current, practical information on the diagnosis and treatment of conditions related to thoracic disease. All the submission and reviewing are conducted electronically so that rapid review is assured.
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