雄激素剥夺疗法治疗晚期前列腺癌的前景。

IF 3 4区医学 Q2 ONCOLOGY

Future oncology Pub Date : 2024-11-18 DOI:10.1080/14796694.2024.2418801

Neal D Shore, Michael S Cookson, Eleni Efstathiou

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引用次数: 0

摘要

在本期播客讨论中，我们将回顾治疗晚期前列腺癌的雄激素剥夺疗法（ADT）的现状。在 2020 年之前，可用于实现化学阉割的 ADT 包括通过肌肉或皮下注射给药的促性腺激素释放激素受体激动剂（如亮丙瑞德）和拮抗剂（如地加瑞克）。2020 年，根据 III 期 HERO 试验的结果，每日一次口服促性腺激素释放激素拮抗剂 relugolix 获得了美国监管部门的批准，用于治疗晚期前列腺癌。在本期播客中，我们还将讨论该试验的主要疗效和安全性结果，以及医疗服务提供者和患者在讨论不同 ADT 方案时需要考虑的要点。

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The landscape of androgen deprivation therapies for the treatment of advanced prostate cancer.

In this podcast discussion, we review the landscape of androgen deprivation therapies (ADT) for the treatment of advanced prostate cancer. Prior to 2020, available ADT options to achieve chemical castration included gonadotropin-releasing hormone receptor agonists (e.g., leuprolide) and antagonists (e.g., degarelix) administered via muscular or subcutaneous injection. In 2020, the once-daily oral gonadotropin-releasing hormone antagonist, relugolix, received US regulatory approval for the treatment of advanced prostate cancer based on results from the Phase III HERO trial. In this podcast, we also discuss the primary efficacy and safety results of this trial, and key points for providers and patients to consider as they discuss the different ADT options.

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来源期刊

Future oncology ONCOLOGY-

CiteScore

5.40

自引率

3.00%

发文量

335

审稿时长

4-8 weeks

期刊介绍： Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.