在 AMD070 类似物上接枝发色团，用于 CXCR4 生物成像：化学合成和体外评估 CXCR4 受体的抑制特性。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-15 DOI:10.1016/j.bmcl.2024.130027

Marie M Le Roy, Cassandra Métivier, Latifa Rbah-Vidal, Patricia Le Saëc, Hela Bouhsine, Michel Chérel, Alain Faivre-Chauvet, Thibault Troadec, Raphaël Tripier

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引用次数: 0

摘要

由于其特殊的药代动力学，使用有机小分子可以替代大分子靶向生物分子（即抗体、肽......）对肿瘤进行特异性成像。在此，我们研究了两种类似 AMD070 的抑制剂作为 CXCR4 靶向单元用于癌细胞特异性成像的潜力，以及发色团接枝对其识别特性的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Grafting a chromophore on AMD070 analogues for CXCR4 bioimaging: Chemical synthesis and in vitro assessment of the inhibition properties of the CXCR4 receptor.

Thank to their particular pharmacokinetics, the use of small organic molecules can be a very promising alternative to macromolecular targeting biomolecules (i.e. antibodies, peptides…) for specific imaging of tumours. Herein, the potential of two AMD070-like inhibitors as CXCR4-targeting units for specific imaging of cancer cells, and the influence of chromophore-grafting on their recognition properties has been investigated.

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来源期刊

Bioorganic & Medicinal Chemistry Letters 医学-医药化学

CiteScore

5.70

自引率

3.70%

发文量

463

审稿时长

27 days

期刊介绍： Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes articles in the form of communications reporting experimental or theoretical results of special interest, and strives to provide maximum dissemination to a large, international audience.