探索塞马鲁肽的抗氧化特性：全面回顾。

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-11-12 DOI:10.1016/j.jdiacomp.2024.108906

Habib Yaribeygi , Mina Maleki , Behina Forouzanmehr , Prashant Kesharwani , Tannaz Jamialahmadi , Sercan Karav , Amirhossein Sahebkar

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引用次数: 0

摘要

糖尿病患者通常会出现自由基产生异常和抗氧化防御功能减弱的情况，这使他们极易受到氧化应激的影响。这反过来又会诱发和促进糖尿病并发症。因此，利用具有抗氧化特性的抗糖尿病药物可以通过解决高血糖和减少氧化损伤带来双重益处。塞马鲁肽是最近获批的一种胰高血糖素样肽-1（GLP-1）类似物口服制剂，已显示出强大的抗糖尿病作用。此外，最近的研究还表明它具有抗氧化特性。然而，人们对其确切的作用和所涉及的分子途径还不甚了解。在这篇综述中，我们将介绍有关塞马鲁肽抗氧化作用的最新发现，并就其中的机制得出结论。

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Exploring the antioxidant properties of semaglutide: A comprehensive review

Patients with diabetes commonly experience an aberrant production of free radicals and weakened antioxidative defenses, making them highly susceptible to oxidative stress development. This, in turn, can induce and promote diabetic complications. Therefore, utilizing antidiabetic agents with antioxidative properties can offer dual benefits by addressing hyperglycemia and reducing oxidative damage. Semaglutide, a recently approved oral form of glucagon-like peptide-1 (GLP-1) analogues, has shown potent antidiabetic effects. Additionally, recent studies have suggested that it possesses antioxidative properties. However, the exact effects and the molecular pathways involved are not well understood. In this review, we present the latest findings on the antioxidative impacts of semaglutide and draw conclusions about the mechanisms involved.

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.