Nilesh Mathuria, Krithik Vishwanath, Giorgio Brero, Blake C. Fallon, Antonio Martino, Richard C. Willson, Carly S. Filgueira, Richard R. Bouchard
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Bouchard","doi":"10.1002/mp.17511","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>A fundamental obstacle for the preclinical development of ultrasound-(US) mediated cardiac imaging remains cardiac motion, which limits interframe correlation during extended acquisition periods.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>To address this need, we present the design and implementation of a 3D-printed vacuum coupler that stabilizes a US transducer on the epicardial surface of the heart for feasibility assessment and development of advanced, cardiac, US-mediated imaging approaches.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The vacuum coupler was 3D printed with biocompatible resins and secured with a standard intraoperative suction aspirator. US-mediated imaging (i.e., B-mode and photoacoustic [PA] imaging) was performed in an open-chest porcine model with and without the vacuum coupler. Based on inter-frame displacement tracking and cross-correlation (CC) coefficients, changes in frame motion and stability were compared for each imaging mode/configuration through a prolonged (∼1 min) acquisition, while the impact on PA-based SO<sub>2</sub> accuracy was assessed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>When compared to conventional handheld imaging, stand-off imaging, and coupler without suction, epicardial imaging with the vacuum coupler and suction applied led to a significantly reduced mean axial displacement of 0.15 mm versus 0.89, 0.49, & 0.49 mm, respectively (<i>p</i>-values ≤ 8.65e-7). Comparing the coupler without suction to that with suction applied, physiologically unrealistic SO<sub>2</sub> estimates reduced from 1.72 to 0.81%, respectively, and lateral interframe displacement reduced from 4.58 to 2.01 mm, respectively (<i>p</i>-value = 5.07e-23). Overall, reduced cardiac tissue motion and increased interframe CC coefficient (baseline = 0.43 vs. coupler with suction = 0.80) allow for more accurate PA unmixing.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Epicardial US-mediated imaging with a vacuum coupler reduces cardiac motion artifact, providing a consistent sampling of an intended region of interest (ROI) over multiple cardiac cycles. This could help facilitate the development of advanced US-mediated imaging, which is often hindered by cardiac motion. Stable implementation of these imaging techniques could allow for intra-operative assessments of local cardiac perfusion as well as tissue characterization.</p>\n </section>\n </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 2","pages":"880-888"},"PeriodicalIF":3.2000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mp.17511","citationCount":"0","resultStr":"{\"title\":\"Open-chest cardiac ultrasound-mediated imaging with a vacuum coupler\",\"authors\":\"Nilesh Mathuria, Krithik Vishwanath, Giorgio Brero, Blake C. Fallon, Antonio Martino, Richard C. Willson, Carly S. Filgueira, Richard R. 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Comparing the coupler without suction to that with suction applied, physiologically unrealistic SO<sub>2</sub> estimates reduced from 1.72 to 0.81%, respectively, and lateral interframe displacement reduced from 4.58 to 2.01 mm, respectively (<i>p</i>-value = 5.07e-23). Overall, reduced cardiac tissue motion and increased interframe CC coefficient (baseline = 0.43 vs. coupler with suction = 0.80) allow for more accurate PA unmixing.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Epicardial US-mediated imaging with a vacuum coupler reduces cardiac motion artifact, providing a consistent sampling of an intended region of interest (ROI) over multiple cardiac cycles. This could help facilitate the development of advanced US-mediated imaging, which is often hindered by cardiac motion. 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引用次数: 0
摘要
背景：目的：为满足这一需求，我们设计并实现了一种三维打印真空耦合器，它能将 US 传感器稳定在心脏外膜表面，用于先进的心脏 US 介导成像方法的可行性评估和开发：真空耦合器是用生物相容性树脂三维打印的，并用标准术中抽吸器固定。在有真空耦合器和没有真空耦合器的开胸猪模型中进行了US介导成像（即B型和光声[PA]成像）。根据帧间位移跟踪和交叉相关（CC）系数，通过长时间（∼1 分钟）采集，比较了每种成像模式/配置的帧运动和稳定性变化，同时评估了对基于 PA 的 SO2 精度的影响：结果：与传统的手持成像、站立成像和无抽吸耦合器相比，使用真空耦合器和抽吸进行心外膜成像可显著减少平均轴向位移，分别为 0.15 毫米、0.89 毫米、0.49 毫米和 0.49 毫米（P 值≤ 8.65e-7）。将无抽吸的耦合器与有抽吸的耦合器进行比较，不符合生理实际的 SO2 估计值分别从 1.72% 降至 0.81%，横向帧间位移分别从 4.58 mm 降至 2.01 mm（p 值 = 5.07e-23）。总体而言，心脏组织运动的减少和帧间 CC 系数的增加（基线 = 0.43 vs. 带抽吸的耦合器 = 0.80）使得 PA 解混更加准确：结论：使用真空耦合器进行心外膜 US-mediated 成像可减少心脏运动伪影，在多个心动周期内提供一致的目标感兴趣区 (ROI) 采样。这将有助于促进先进的 US 介导成像技术的发展，而这种成像技术通常会受到心脏运动的阻碍。这些成像技术的稳定实施可以在术中评估局部心脏灌注以及组织特征。
Open-chest cardiac ultrasound-mediated imaging with a vacuum coupler
Background
A fundamental obstacle for the preclinical development of ultrasound-(US) mediated cardiac imaging remains cardiac motion, which limits interframe correlation during extended acquisition periods.
Purpose
To address this need, we present the design and implementation of a 3D-printed vacuum coupler that stabilizes a US transducer on the epicardial surface of the heart for feasibility assessment and development of advanced, cardiac, US-mediated imaging approaches.
Methods
The vacuum coupler was 3D printed with biocompatible resins and secured with a standard intraoperative suction aspirator. US-mediated imaging (i.e., B-mode and photoacoustic [PA] imaging) was performed in an open-chest porcine model with and without the vacuum coupler. Based on inter-frame displacement tracking and cross-correlation (CC) coefficients, changes in frame motion and stability were compared for each imaging mode/configuration through a prolonged (∼1 min) acquisition, while the impact on PA-based SO2 accuracy was assessed.
Results
When compared to conventional handheld imaging, stand-off imaging, and coupler without suction, epicardial imaging with the vacuum coupler and suction applied led to a significantly reduced mean axial displacement of 0.15 mm versus 0.89, 0.49, & 0.49 mm, respectively (p-values ≤ 8.65e-7). Comparing the coupler without suction to that with suction applied, physiologically unrealistic SO2 estimates reduced from 1.72 to 0.81%, respectively, and lateral interframe displacement reduced from 4.58 to 2.01 mm, respectively (p-value = 5.07e-23). Overall, reduced cardiac tissue motion and increased interframe CC coefficient (baseline = 0.43 vs. coupler with suction = 0.80) allow for more accurate PA unmixing.
Conclusions
Epicardial US-mediated imaging with a vacuum coupler reduces cardiac motion artifact, providing a consistent sampling of an intended region of interest (ROI) over multiple cardiac cycles. This could help facilitate the development of advanced US-mediated imaging, which is often hindered by cardiac motion. Stable implementation of these imaging techniques could allow for intra-operative assessments of local cardiac perfusion as well as tissue characterization.
期刊介绍：
Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments
Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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