识别韩国 2 型糖尿病患者的代谢模式及其与糖尿病相关并发症的关系。

Diabetes Pub Date : 2025-02-01 DOI:10.2337/db23-0798

Minji Kang, Kumhee Son, You-Cheol Hwang, Sihoon Lee, Hyunji Sang, Sunyoung Kim, Dong Keon Yon, Sang Youl Rhee, Hyunjung Lim

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引用次数: 0

摘要

解决 2 型糖尿病（T2DM）患者的代谢异质性问题可使他们获得精准医疗。尽管 T2DM 患者的病理生理过程存在种族差异，但与亚洲人临床特征相关的糖尿病亚型研究却不足。本研究旨在确定大韩民国（韩国）T2DM 中年患者的代谢模式，并根据模式确定糖尿病相关并发症的发病率。我们分析了在韩国三家综合医院中心就诊的 6603 名 30 至 64 岁的 T2DM 患者。得出了三种代谢模式：肥胖和高血压模式（OH-P）、肝功能相关高血糖模式（LFHG-P）和肾功能减退模式（DKF-P）。与最低三分位数相比，OH-P 评分的最高三分位数与外周血管疾病风险的增加有关（HR = 1.26，95% CI = 1.02-1.57）。LFHG-P 评分的最高三分位数与心肌梗死（HR = 1.79，95% CI = 1.13-2.82）和心房颤动（HR = 1.54，95% CI = 1.07-2.23）风险增加有关。DKF-P与并发症没有关联。这项研究表明，有必要根据 T2DM 患者的代谢模式进行适当的管理和治疗。

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Identification of Metabolic Patterns in Korean Patients With Type 2 Diabetes and Their Association With Diabetes-Related Complications.

Article highlights: Identifying patterns of metabolic heterogeneity in type 2 diabetes (T2D) can help in the development of optimal treatment strategies. We aimed to identify metabolic patterns in patients with T2D in the Republic of Korea and analyze the risk of developing diabetes-related complications according to patterns. We identified three distinct metabolic patterns and observed that each pattern was associated with a heightened risk of developing various cardiovascular diseases. These findings highlight the necessity of devising treatment strategies based on these patterns to prevent diabetes-related complications.

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Diabetes

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