Min Hong, Ziying Lin, Hua Zhong, Yan Zhang, Dan Yang, Sihui Zhong, Xiangrong Zhuang, Xin Yue
{"title":"利用双能量 CT 导出的斜率参数图像提高克罗恩病的诊断性能","authors":"Min Hong, Ziying Lin, Hua Zhong, Yan Zhang, Dan Yang, Sihui Zhong, Xiangrong Zhuang, Xin Yue","doi":"10.1007/s10278-024-01330-4","DOIUrl":null,"url":null,"abstract":"<p><p>The objective of the study is to explore the image quality and diagnosis performance of the dual-energy CT-derived slope parameter images (SPI) generated by the algorithm based on the slope function in the diagnosis of Crohn's disease (CD). Seventy-six CD patients and 53 disease-free control group subjects who underwent dual-energy CT enterography were retrospectively collected. Portal venous phase 120kVp-like and virtual monoenergetic images at 40-100 keV (VMI<sub>40-100</sub>) were reconstructed. SPIs corresponding to the spectral curve between 40 and 100 keV (SPI<sub>40-100</sub>) were generated using Python. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of normal and abnormal intestinal walls were calculated. Image quality, noise, and contrast were independently scored by two radiologists using a 5-point scale. Four radiologists conducted CD diagnosis with three reading models (120kVp-like, 120kVp-like with optimal VMI, and 120kVp-like with SPI<sub>40-100</sub>). The diagnostic performances of the three reading models for diagnosing CD were evaluated using receiver operating characteristic (ROC) curves. The CNR in SPI<sub>40-100</sub> was higher than in the other images (P < 0.05). The subjective evaluation showed that there was no statistical difference between the contrast of SPI<sub>40-100</sub> and VMI<sub>40</sub> (P > 0.05), but that of the two images was higher than the other images (P < 0.05). The scoring on the overall image quality of VMI<sub>50</sub> was superior to that of other images (P < 0.05). The combined model of 120kVp-like with SPI<sub>40-100</sub> had the strongest confidence (cases with high confidence: 36, 58, 49, 47 for radiologists 1, 2, 3, 4) and the highest efficiency in diagnosing CD (areas under the ROC curve: 0.973, 0.977, 0.982, 0.991 for radiologists 1, 2, 3, 4). SPI<sub>40-100</sub> generated by the algorithm based on the slope function exhibited good image quality. The combined model of 120kVp-like with SPI<sub>40-100</sub> could improve radiologists' diagnostic efficiency and confidence in diagnosing CD.</p>","PeriodicalId":516858,"journal":{"name":"Journal of imaging informatics in medicine","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Improved Diagnostic Performance Using Dual-Energy CT-Derived Slope Parameter Images in Crohn's Disease.\",\"authors\":\"Min Hong, Ziying Lin, Hua Zhong, Yan Zhang, Dan Yang, Sihui Zhong, Xiangrong Zhuang, Xin Yue\",\"doi\":\"10.1007/s10278-024-01330-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The objective of the study is to explore the image quality and diagnosis performance of the dual-energy CT-derived slope parameter images (SPI) generated by the algorithm based on the slope function in the diagnosis of Crohn's disease (CD). Seventy-six CD patients and 53 disease-free control group subjects who underwent dual-energy CT enterography were retrospectively collected. Portal venous phase 120kVp-like and virtual monoenergetic images at 40-100 keV (VMI<sub>40-100</sub>) were reconstructed. SPIs corresponding to the spectral curve between 40 and 100 keV (SPI<sub>40-100</sub>) were generated using Python. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of normal and abnormal intestinal walls were calculated. Image quality, noise, and contrast were independently scored by two radiologists using a 5-point scale. Four radiologists conducted CD diagnosis with three reading models (120kVp-like, 120kVp-like with optimal VMI, and 120kVp-like with SPI<sub>40-100</sub>). The diagnostic performances of the three reading models for diagnosing CD were evaluated using receiver operating characteristic (ROC) curves. The CNR in SPI<sub>40-100</sub> was higher than in the other images (P < 0.05). The subjective evaluation showed that there was no statistical difference between the contrast of SPI<sub>40-100</sub> and VMI<sub>40</sub> (P > 0.05), but that of the two images was higher than the other images (P < 0.05). The scoring on the overall image quality of VMI<sub>50</sub> was superior to that of other images (P < 0.05). The combined model of 120kVp-like with SPI<sub>40-100</sub> had the strongest confidence (cases with high confidence: 36, 58, 49, 47 for radiologists 1, 2, 3, 4) and the highest efficiency in diagnosing CD (areas under the ROC curve: 0.973, 0.977, 0.982, 0.991 for radiologists 1, 2, 3, 4). SPI<sub>40-100</sub> generated by the algorithm based on the slope function exhibited good image quality. The combined model of 120kVp-like with SPI<sub>40-100</sub> could improve radiologists' diagnostic efficiency and confidence in diagnosing CD.</p>\",\"PeriodicalId\":516858,\"journal\":{\"name\":\"Journal of imaging informatics in medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of imaging informatics in medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s10278-024-01330-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of imaging informatics in medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10278-024-01330-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Improved Diagnostic Performance Using Dual-Energy CT-Derived Slope Parameter Images in Crohn's Disease.
The objective of the study is to explore the image quality and diagnosis performance of the dual-energy CT-derived slope parameter images (SPI) generated by the algorithm based on the slope function in the diagnosis of Crohn's disease (CD). Seventy-six CD patients and 53 disease-free control group subjects who underwent dual-energy CT enterography were retrospectively collected. Portal venous phase 120kVp-like and virtual monoenergetic images at 40-100 keV (VMI40-100) were reconstructed. SPIs corresponding to the spectral curve between 40 and 100 keV (SPI40-100) were generated using Python. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of normal and abnormal intestinal walls were calculated. Image quality, noise, and contrast were independently scored by two radiologists using a 5-point scale. Four radiologists conducted CD diagnosis with three reading models (120kVp-like, 120kVp-like with optimal VMI, and 120kVp-like with SPI40-100). The diagnostic performances of the three reading models for diagnosing CD were evaluated using receiver operating characteristic (ROC) curves. The CNR in SPI40-100 was higher than in the other images (P < 0.05). The subjective evaluation showed that there was no statistical difference between the contrast of SPI40-100 and VMI40 (P > 0.05), but that of the two images was higher than the other images (P < 0.05). The scoring on the overall image quality of VMI50 was superior to that of other images (P < 0.05). The combined model of 120kVp-like with SPI40-100 had the strongest confidence (cases with high confidence: 36, 58, 49, 47 for radiologists 1, 2, 3, 4) and the highest efficiency in diagnosing CD (areas under the ROC curve: 0.973, 0.977, 0.982, 0.991 for radiologists 1, 2, 3, 4). SPI40-100 generated by the algorithm based on the slope function exhibited good image quality. The combined model of 120kVp-like with SPI40-100 could improve radiologists' diagnostic efficiency and confidence in diagnosing CD.
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