连接三年的洞察力:研究抑郁症与胆石症之间的关联。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Journal of clinical medicine research Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI:10.14740/jocmr6050
Huai Zhi Wang, Saboor Saeed, Jin Yu Zhang, Shao Hua Hu
{"title":"连接三年的洞察力:研究抑郁症与胆石症之间的关联。","authors":"Huai Zhi Wang, Saboor Saeed, Jin Yu Zhang, Shao Hua Hu","doi":"10.14740/jocmr6050","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Despite sharing common pathophysiological risk factors, the relationship between gallstones and depression requires further evidence for a clearer understanding. This study combines the National Health and Nutrition Examination Survey 2017 - 2020 observational data and Mendelian randomization (MR) analysis to shed light on the potential correlation between these conditions.</p><p><strong>Methods: </strong>By analyzing the National Health and Nutrition Examination Survey 2017 - 2020 data through weighted multivariable-adjusted logistic regression, we examined the association between depression and gallstone risk. MR was subsequently applied, utilizing genetic instruments from a large genome-wide association study on depression (excluding 23andMe, 500,199 participants) and gallstone data (28,627 cases, 348,373 controls), employing the main inverse variance-weighted method alongside other MR methods to explore the causal relationship. Sensitivity analyses validated the study's conclusions.</p><p><strong>Results: </strong>Among the 5,303 National Health and Nutrition Examination Survey participants, a significant association was found between depressive symptoms and increased gallstone risk (initial odds ratio (OR) = 2.001; 95% confidence interval (CI) = 1.523 - 2.598; P < 0.001), with the association persisting after comprehensive adjustments (final OR = 1.687; 95% CI = 1.261 - 2.234; P < 0.001). MR findings also indicated a causal link between genetically predicted depression and higher gallstone risk (OR = 1.164; 95% CI = 1.053 - 1.286; P = 0.003).</p><p><strong>Conclusions: </strong>Depression is significantly associated with a higher risk of gallstones, supported by genetic evidence suggesting a causal link. These findings highlight the importance of considering depression in gallstone risk assessments and management strategies.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"16 10","pages":"472-482"},"PeriodicalIF":1.6000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557501/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bridging Three Years of Insights: Examining the Association Between Depression and Gallstone Disease.\",\"authors\":\"Huai Zhi Wang, Saboor Saeed, Jin Yu Zhang, Shao Hua Hu\",\"doi\":\"10.14740/jocmr6050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Despite sharing common pathophysiological risk factors, the relationship between gallstones and depression requires further evidence for a clearer understanding. This study combines the National Health and Nutrition Examination Survey 2017 - 2020 observational data and Mendelian randomization (MR) analysis to shed light on the potential correlation between these conditions.</p><p><strong>Methods: </strong>By analyzing the National Health and Nutrition Examination Survey 2017 - 2020 data through weighted multivariable-adjusted logistic regression, we examined the association between depression and gallstone risk. MR was subsequently applied, utilizing genetic instruments from a large genome-wide association study on depression (excluding 23andMe, 500,199 participants) and gallstone data (28,627 cases, 348,373 controls), employing the main inverse variance-weighted method alongside other MR methods to explore the causal relationship. Sensitivity analyses validated the study's conclusions.</p><p><strong>Results: </strong>Among the 5,303 National Health and Nutrition Examination Survey participants, a significant association was found between depressive symptoms and increased gallstone risk (initial odds ratio (OR) = 2.001; 95% confidence interval (CI) = 1.523 - 2.598; P < 0.001), with the association persisting after comprehensive adjustments (final OR = 1.687; 95% CI = 1.261 - 2.234; P < 0.001). MR findings also indicated a causal link between genetically predicted depression and higher gallstone risk (OR = 1.164; 95% CI = 1.053 - 1.286; P = 0.003).</p><p><strong>Conclusions: </strong>Depression is significantly associated with a higher risk of gallstones, supported by genetic evidence suggesting a causal link. These findings highlight the importance of considering depression in gallstone risk assessments and management strategies.</p>\",\"PeriodicalId\":94329,\"journal\":{\"name\":\"Journal of clinical medicine research\",\"volume\":\"16 10\",\"pages\":\"472-482\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557501/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical medicine research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14740/jocmr6050\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical medicine research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/jocmr6050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

背景:尽管胆结石与抑郁症具有共同的病理生理风险因素,但两者之间的关系还需要进一步的证据才能得到更清晰的认识。本研究结合 2017 - 2020 年全国健康与营养调查的观察数据和孟德尔随机化(MR)分析,揭示了这些疾病之间的潜在相关性:通过加权多变量调整逻辑回归分析2017 - 2020年国家健康与营养调查数据,我们研究了抑郁症与胆结石风险之间的关联。随后,我们利用大型抑郁症全基因组关联研究的遗传工具(不包括 23andMe,500 199 名参与者)和胆结石数据(28 627 个病例,348 373 个对照),采用主逆方差加权法和其他 MR 方法来探讨因果关系。敏感性分析验证了研究结论:在 5,303 名全国健康与营养调查参与者中,发现抑郁症状与胆结石风险增加之间存在显著关联(初始比值比 (OR) = 2.001; 95% 置信区间 (CI) = 1.523 - 2.598; P < 0.001),经全面调整后,该关联仍然存在(最终比值比 = 1.687; 95% 置信区间 = 1.261 - 2.234; P < 0.001)。MR研究结果还表明,遗传预测的抑郁与较高的胆石风险之间存在因果关系(OR = 1.164; 95% CI = 1.053 - 1.286; P = 0.003):结论:抑郁症与胆结石风险较高密切相关,遗传学证据表明两者之间存在因果关系。这些发现强调了在胆结石风险评估和管理策略中考虑抑郁症的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bridging Three Years of Insights: Examining the Association Between Depression and Gallstone Disease.

Background: Despite sharing common pathophysiological risk factors, the relationship between gallstones and depression requires further evidence for a clearer understanding. This study combines the National Health and Nutrition Examination Survey 2017 - 2020 observational data and Mendelian randomization (MR) analysis to shed light on the potential correlation between these conditions.

Methods: By analyzing the National Health and Nutrition Examination Survey 2017 - 2020 data through weighted multivariable-adjusted logistic regression, we examined the association between depression and gallstone risk. MR was subsequently applied, utilizing genetic instruments from a large genome-wide association study on depression (excluding 23andMe, 500,199 participants) and gallstone data (28,627 cases, 348,373 controls), employing the main inverse variance-weighted method alongside other MR methods to explore the causal relationship. Sensitivity analyses validated the study's conclusions.

Results: Among the 5,303 National Health and Nutrition Examination Survey participants, a significant association was found between depressive symptoms and increased gallstone risk (initial odds ratio (OR) = 2.001; 95% confidence interval (CI) = 1.523 - 2.598; P < 0.001), with the association persisting after comprehensive adjustments (final OR = 1.687; 95% CI = 1.261 - 2.234; P < 0.001). MR findings also indicated a causal link between genetically predicted depression and higher gallstone risk (OR = 1.164; 95% CI = 1.053 - 1.286; P = 0.003).

Conclusions: Depression is significantly associated with a higher risk of gallstones, supported by genetic evidence suggesting a causal link. These findings highlight the importance of considering depression in gallstone risk assessments and management strategies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
5.10
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信