S.N. Seyedin , G.K. Harada , E. Garemanian , D. Rafizadeh , D. Kaakour , S. Dwabe , A. Rezazadeh , M. Daneshvar , N. Mar
{"title":"转移性尿路上皮癌放疗与恩福单抗维多汀联合用药的安全性分析","authors":"S.N. Seyedin , G.K. Harada , E. Garemanian , D. Rafizadeh , D. Kaakour , S. Dwabe , A. Rezazadeh , M. Daneshvar , N. Mar","doi":"10.1016/j.clgc.2024.102243","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction/Background</h3><div>Enfortumab vedotin (EV) and pembrolizumab (P) is the standard of care for patients with locally advanced or metastatic urothelial carcinoma (la/mUC). Because radiation (RT) is frequently used for symptom palliation, we examined the safety of co-administering EV with RT.</div></div><div><h3>Materials and Methods</h3><div>This single institution retrospective study selected patients with la/mUC, who received at least 1 dose of EV and initiated RT to any site within 30 days of each other. Patient characteristics, number of EV cycles received, the location of irradiated sites, RT dose/delivery approach, severity/type of radiation treatment-related adverse events (TRAEs), and symptom response after RT were recorded. The primary aim of this study was to examine radiation TRAEs, with severity graded using the CTCAE version 5.0 classification.</div></div><div><h3>Results</h3><div>Nine patients with 15 irradiated metastasis met eligibility criteria. The median radiation dose and cycles of EV were 30 Gy and 5 cycles respectively. Patients only experienced acute grade 1 or 2 TRAEs including fatigue, nausea, and dermatitis without desquamation. Chronic treatment-related toxicity was noted in 2 patients, which were grade 1 neck pain and 2 fatigue. All patients demonstrated some degree of symptom relief and four experienced complete resolution of their cancer-related symptoms at the irradiated site. One patient with limited disease burden completed stereotactic body radiation therapy and remains disease free 6 months after discontinuing all treatment.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that co-administration of RT with EV-based regimens could be safe and effective for symptom palliation. Larger series examining this treatment combination are needed.</div></div>","PeriodicalId":10380,"journal":{"name":"Clinical genitourinary cancer","volume":"22 6","pages":"Article 102243"},"PeriodicalIF":2.3000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Safety Analysis of Co-Administration of Radiation Therapy with Enfortumab Vedotin Based Regimens in Metastatic Urothelial Carcinoma\",\"authors\":\"S.N. Seyedin , G.K. Harada , E. Garemanian , D. Rafizadeh , D. Kaakour , S. Dwabe , A. Rezazadeh , M. Daneshvar , N. Mar\",\"doi\":\"10.1016/j.clgc.2024.102243\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction/Background</h3><div>Enfortumab vedotin (EV) and pembrolizumab (P) is the standard of care for patients with locally advanced or metastatic urothelial carcinoma (la/mUC). Because radiation (RT) is frequently used for symptom palliation, we examined the safety of co-administering EV with RT.</div></div><div><h3>Materials and Methods</h3><div>This single institution retrospective study selected patients with la/mUC, who received at least 1 dose of EV and initiated RT to any site within 30 days of each other. Patient characteristics, number of EV cycles received, the location of irradiated sites, RT dose/delivery approach, severity/type of radiation treatment-related adverse events (TRAEs), and symptom response after RT were recorded. The primary aim of this study was to examine radiation TRAEs, with severity graded using the CTCAE version 5.0 classification.</div></div><div><h3>Results</h3><div>Nine patients with 15 irradiated metastasis met eligibility criteria. The median radiation dose and cycles of EV were 30 Gy and 5 cycles respectively. Patients only experienced acute grade 1 or 2 TRAEs including fatigue, nausea, and dermatitis without desquamation. Chronic treatment-related toxicity was noted in 2 patients, which were grade 1 neck pain and 2 fatigue. All patients demonstrated some degree of symptom relief and four experienced complete resolution of their cancer-related symptoms at the irradiated site. One patient with limited disease burden completed stereotactic body radiation therapy and remains disease free 6 months after discontinuing all treatment.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that co-administration of RT with EV-based regimens could be safe and effective for symptom palliation. Larger series examining this treatment combination are needed.</div></div>\",\"PeriodicalId\":10380,\"journal\":{\"name\":\"Clinical genitourinary cancer\",\"volume\":\"22 6\",\"pages\":\"Article 102243\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical genitourinary cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1558767324002131\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical genitourinary cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1558767324002131","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Safety Analysis of Co-Administration of Radiation Therapy with Enfortumab Vedotin Based Regimens in Metastatic Urothelial Carcinoma
Introduction/Background
Enfortumab vedotin (EV) and pembrolizumab (P) is the standard of care for patients with locally advanced or metastatic urothelial carcinoma (la/mUC). Because radiation (RT) is frequently used for symptom palliation, we examined the safety of co-administering EV with RT.
Materials and Methods
This single institution retrospective study selected patients with la/mUC, who received at least 1 dose of EV and initiated RT to any site within 30 days of each other. Patient characteristics, number of EV cycles received, the location of irradiated sites, RT dose/delivery approach, severity/type of radiation treatment-related adverse events (TRAEs), and symptom response after RT were recorded. The primary aim of this study was to examine radiation TRAEs, with severity graded using the CTCAE version 5.0 classification.
Results
Nine patients with 15 irradiated metastasis met eligibility criteria. The median radiation dose and cycles of EV were 30 Gy and 5 cycles respectively. Patients only experienced acute grade 1 or 2 TRAEs including fatigue, nausea, and dermatitis without desquamation. Chronic treatment-related toxicity was noted in 2 patients, which were grade 1 neck pain and 2 fatigue. All patients demonstrated some degree of symptom relief and four experienced complete resolution of their cancer-related symptoms at the irradiated site. One patient with limited disease burden completed stereotactic body radiation therapy and remains disease free 6 months after discontinuing all treatment.
Conclusion
This study demonstrates that co-administration of RT with EV-based regimens could be safe and effective for symptom palliation. Larger series examining this treatment combination are needed.
期刊介绍:
Clinical Genitourinary Cancer is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research in genitourinary cancers. Clinical Genitourinary Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of genitourinary cancers. The main emphasis is on recent scientific developments in all areas related to genitourinary malignancies. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.