调查肠道微生物群对出血性中风风险的因果效应：孟德尔随机研究。

IF 2 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2024-11-09 DOI:10.1016/j.jstrokecerebrovasdis.2024.108131

Jiaxin Li MD , Chenyang Zang MD , Peihong Li MD , Dandan Sheng MD , Zheng Xiao MD , Bo Xiao MD, PhD , Jian Xia MD , Luo Zhou MD

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引用次数: 0

摘要

背景：出血性脑卒中可能致命并使人衰弱。以前的研究表明，肠道微生物群与出血性中风之间存在潜在的相关性：我们进行了一项双样本孟德尔随机化（MR）研究，以评估肠道微生物群对出血性中风（包括非创伤性颅内出血（ntICH）、脑内出血（ICH）和蛛网膜下腔出血（SAH））的潜在因果效应。反方差加权（IVW）法被用作主要的磁共振评估方法。此外，还采用了 MR-Egger、简单模式、加权模式和加权中值等补充方法。使用 Cochran's Q 和 MR-Egger 截距检验评估了异质性和多义性。采用MR-PRESSO和leave-one-out分析来识别工具异常值：结果：IVW 估计值表明，ntICH 风险与两个类（梭菌属、甲烷杆菌）、一个目（甲烷杆菌科）、两个科（梭菌属 vadin BB60 组、甲烷杆菌科）和两个属（卡氏菌属、未知属 id.1000000073）的类群之间存在显著关联（结论：我们的研究结果为 ntICH 的因果关系提供了支持：我们的研究结果为特定肠道微生物类群对出血性中风的因果效应提供了支持，并为其预防和治疗确定了有前景的靶点。还需要进一步研究来验证这些关联。

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Investigating the role of gut microbiota in hemorrhagic stroke: Evidence from causal analysis

Background

Hemorrhagic stroke is potentially fatal and debilitating. Previous studies have indicated a potential correlation between gut microbiota and hemorrhagic stroke.

Methods

We conducted a two-sample Mendelian randomization (MR) study to assess the potential causal effects of gut microbiota on hemorrhagic stroke, including nontraumatic intracranial hemorrhage (ntICH), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). The inverse variance weighted (IVW) method was employed as the primary MR evaluation approach. Complementary methods of MR‒Egger, simple mode, weighted mode, and weighted median were utilized for validation. Heterogeneity and pleiotropy were assessed using Cochran's Q and MR‒Egger intercept tests. MR-PRESSO and leave-one-out analyses were employed to identify instrumental outliers.

Results

The IVW estimates demonstrated significant causal associations between ntICH and taxa from two classes (Clostridia, Methanobacteria), one order (Methanobacteriales), two families (Clostridiales vadin BB60 group, Methanobacteriaceae), and two genera (Catenibacterium, unknown genus id. 1000000073) (P<0.05). Subgroup analyses revealed causal links between ICH and taxa from two classes (Clostridia, Methanobacteria), two orders (Methanobacteriales, Rhodospirillales), two families (Acidaminococcaceae, Methanobacteriaceae), and four genera (Butyricimonas, Catenibacterium, Lachnospiraceae UCG010, unknown genus id.2755) (P<0.05). Furthermore, for the SAH subgroup, we identified causal associations with taxa from one family (Rikenellaceae) and six genera (Alloprevotella, Enterorhabdus, Hungatella, Lachnoclostridium, Parabacteroides, Ruminococcus gauvreauii group) (P<0.05). These findings remained robust across all sensitivity tests.

Conclusions

Our findings provide support for the causal effects of specific gut microbial taxa on hemorrhagic stroke and identify promising targets for its prevention and therapy. Further research is warranted to validate these associations.

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.