上海市浦东新区社区居民的中国人内脏脂肪指数与脑卒中发病率之间的关系。

IF 2 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2024-11-08 DOI:10.1016/j.jstrokecerebrovasdis.2024.108100

Qingping Liu, Yi Zhou, Kang Wu, Jiahui Song, Juzhong Ke, Hua Qiu, Zhitao Li, Xiaonan Ruan

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引用次数: 0

摘要

背景：分析浦东新区中国人内脏脂肪指数（CVAI）与脑卒中的关系，为该病的预防和治疗提供科学依据：分析浦东新区中国人内脏脂肪指数（CVAI）与脑卒中的关系，为脑卒中的防治提供科学依据：基于 "浦东新区慢性病危险因素队列随访项目"，选取浦东新区12个乡镇、35个村委会或居委会共7194名居民作为研究对象。以2016年的队列数据为基线，2019年至2020年对5462人进行了随访：在脑卒中发病率分析中，共纳入 5462 名受试者，记录了 616 起脑卒中事件。脑卒中的发病密度为每千人年 33.41 例，而中国标准发病率和世界标准发病率分别为每千人年 13.78 例和 12.52 例。脑卒中的发病密度随着 CVAI 四分位数的增加而上升。在调整了潜在的混杂因素后，CVAI≥132.11 的男性和女性与 CVAI＜81.91 的人群相比，脑卒中风险分别为 2.492 倍（95% CI：1.457 ∼ 4.260）和 1.759 倍（95% CI：1.070 ∼ 2.891）。在八项肥胖指标中，包括 CVAI、内脏脂肪指数 (VAI)、体重指数 (BMI)、腰围 (WC)、腰臀比 (WHR)、腰高比 (WHTR)、身体脂肪指数 (BAI)、根据接收者特征曲线（ROC），CVAI 对女性中风的诊断准确率最高（ROC 曲线下面积/AUC = 0.619）。619).亚组分析显示，吸烟和血脂异常会显著改变女性 CVAI 与中风风险之间的关联（交互作用 P < 0.05）：结论：CVAI 是脑卒中的重要危险因素，是预测脑卒中的重要指标，尤其是对女性而言。

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Associations between chinese visceral adiposity index and incident stroke among community populations in Pudong New Area, Shanghai

Background

To analyze the relationship between Chinese Visceral Adiposity Index (CVAI) and stroke in Pudong New Area, and to provide a scientific basis for the prevention and treatment of this condition.

Materials and Methods

Based on the Follow-up Cohort Program of Chronic Disease Risk Factors in Pudong New Area, a total of 7,194 residents from 12 townships and 35 village committees or neighborhood committees were selected. The cohort data in 2016 served as the baseline, and a follow-up was conducted on 5462 individuals from 2019 to 2020.

Results

In the analysis of stroke incidence, 5,462 subjects were included, with 616 stroke events recorded. The incidence density of stroke was 33.41 per 1000 person-years, while the China standard rate and the world standard rate were 13.78 and 12.52 per 1000 person-years, respectively. The incidence density of stroke rose with increasing quartiles of CVAI. After adjusting for potential confounders, the risk of stroke for males and females with CVAI ≥ 132.11 was 2.492 times (95% CI: 1.457 ∼ 4.260) and 1.759 times (95% CI: 1.070-2.891), respectively, compared to the groups with CVAI < 81.91. Among the eight obesity indicators, including CVAI, Visceral Adiposity Index (VAI), Body Mass Index (BMI), Waist Circumference (WC), Waist Hip Ratio (WHR), Waist Height Ratio (WHtR), Body Adiposity Index (BAI), A Body Shape Index (ABSI),and Body Roundness Index (BRI), CVAI has the highest diagnostic accuracy for female stroke using Receiver Operator Characteristic (ROC) curves (the Area under the ROC curve/AUC = 0.619). Subgroup analysis showed that smoking and dyslipidemia significantly modified the association between CVAI and stroke risk in females (interaction P < 0.05).

Conclusions

CVAI is identified as a significant risk factor for stroke and serves as a valuable predictor of stroke, particularly in females.

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.