急性脑内出血患者载脂蛋白 E 基因多态性与早期 MR 检查结果之间的关系：一项回顾性队列分析。

IF 2 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2024-11-10 DOI:10.1016/j.jstrokecerebrovasdis.2024.108128

Zhenjie Yang M.B. , Qiuxia Xiong M.B. , Rui He M.B. , Chuyue Wu M.D., Ph.D. , Yu Huang M.M. , Qian Li B.N. , Xinghua Liu M.M.

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引用次数: 0

摘要

目的：载脂蛋白 E（APOE）基因在脑内出血（ICH）的发病和预后中起着重要作用。在 ICH 发病 48 小时内发现的影像学特征，尤其是在磁共振成像（MRI）上发现的特征，表明存在脑小血管疾病（CSVD）。我们的研究旨在评估这些成像特征，并调查它们与 ICH 患者 APOE 基因的关系：收集了 2021 年 10 月至 2022 年 3 月期间符合特定纳入和排除标准的患者的临床和影像学数据。按照国际认证标准对 MR 征象或评分进行评估，然后分析其与 APOE 等位基因的关系：结果：在一组 220 例患者中，ε2 被确定为 "多皮层下斑点 "征的独立危险因素（OR = 13.29，95% CI 1.88-22.59）。此外，ε4 是半叶中心（OR = 2.46，95% CI 1.03-5.89）和基底节（OR = 2.64，95% CI 1.10-6.35）出现血管周围间隙（PVS）的独立危险因素。结论：APOE Ⅺ与脑微小出血（CMB）、脑叶CMB（OR = 2.92，95% CI 1.11-7.65）和深部CMB（OR = 2.29，95% CI 1.12-8.67）之间存在关联：APOEɛ2和ɛ4等位基因与 "皮层下多发性斑点"、"PVS "和 "CMB "之间的关联间接暗示了APOE基因相关病理改变在ICH和小血管病变进展中的潜在作用。

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Association between apolipoprotein E gene polymorphism and early MR findings in individuals with acute intracerebral hemorrhage: A retrospective cohort analysis

Objective

The Apolipoprotein E (APOE) gene plays a significant role in the development and prognosis of intracerebral hemorrhage (ICH). Imaging features identified within 48 h of ICH onset, particularly on magnetic resonance imaging (MRI), are indicative of cerebral small vessel diseases (CSVD). Our study aimed to assess these imaging characteristics and investigate their association with the APOE gene among ICH patients.

Methods

Clinical and imaging data from patients meeting specific inclusion and exclusion criteria from October 2021 to March 2022 were collected. MR signs or scores were evaluated following international accreditation standards and then analyzed in connection with the APOE allele genes.

Results

In a cohort of 220 patients, ε2 was identified as an independent risk factor for the “multiple subcortical spots” sign (OR = 13.29, 95% CI 1.88-22.59). Furthermore, ε4 emerged as an independent risk factor for the presence of perivascular space (PVS) in the centrum semiovale (OR = 2.46, 95% CI 1.03-5.89) and basal ganglia (OR = 2.64, 95% CI 1.10-6.35), as well as for cerebral microbleeds (CMB) across all locations (OR = 2.38, 95% CI 1.15-6.97), lobar CMB (OR = 2.92, 95% CI 1.11-7.65), and deep CMB (OR = 2.29, 95% CI 1.12-8.67).

Conclusion

The association between APOE ɛ2 and ɛ4 alleles and the presence of “subcortical multiple spots,” “PVS,” and “CMB” indirectly implies the potential role of APOE gene-related pathological changes in the progression of ICH and small vessel pathology.

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.