前列腺癌激素治疗对患者生活质量和心理关系领域影响的研究》：ProQoL.

IF 3.2 Q2 ONCOLOGY

Oncology and Therapy Pub Date : 2024-11-13 DOI:10.1007/s40487-024-00313-3

Francesca Cappuccio, Carlo Buonerba, Luca Scafuri, Rossella Di Trolio, Pasquale Dolce, Serena Orsola Trabucco, Filomena Erbetta, Elvira Tulimieri, Antonella Sciscio, Concetta Ingenito, Antonio Verde, Giuseppe Di Lorenzo

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引用次数: 0

摘要

导言：前列腺癌及其治疗，尤其是雄激素剥夺疗法（ADT），会对患者的生活质量产生深远影响。本文报告的前瞻性观察研究旨在评估 ADT 对意大利南部一家社区医院前列腺癌男性患者生活质量各个方面的影响：方法：在 2021 年 12 月至 2023 年 12 月期间招募符合条件的男性患者开始接受激素治疗。使用标准化问卷（欧洲癌症研究和治疗组织 [EORTC] QLQ-C30、EORTC QLQ-PR25）和半结构化访谈收集基线（T0）以及 ADT 3 个月（T1）和 6 个月（T2）后的数据：在 52 名参与者中，43 人完成了所有三项评估。EORTC QLQ-C30显示身体功能有显著的统计学恶化（平均分从T0时的83.8分降至T2时的76.7分；P 结论：ADT显著影响了患者生活质量的各个方面：ADT 对男性前列腺癌患者生活质量的各个方面都有明显影响，尤其是身体机能、疲劳、性功能、身体形象和情绪健康。这些结果凸显了以患者为中心的综合治疗方法的重要性，这种方法既能解决身体方面的问题，也能解决社会心理方面的问题。

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Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL.

Introduction: Prostate cancer and its treatment, particularly androgen deprivation therapy (ADT), can profoundly impact patients' quality of life. The aim of the prospective observational study reported here was to evaluate the effects of ADT on various aspects of quality of life in men with prostate cancer at a community-based hospital in Southern Italy.

Methods: Eligible men initiating hormonal therapy were recruited between December 2021 and December 2023. Data were collected at baseline (T₀) and after 3 months (T₁) and 6 months (T₂) of ADT using standardized questionnaires (European Organization for Research and Treatment of Cancer [EORTC] QLQ-C30, EORTC QLQ-PR25) and semi-structured interviews.

Results: Of the 52 participants, 43 completed all three assessments. The EORTC QLQ-C30 showed a statistically significant worsening in physical functioning (mean score decrease from 83.8 at T₀ to 76.7 at T₂; p < 0.001), increased fatigue (from 23.7 to 35.2; p < 0.001), and insomnia (from 23.7 to 31.8; p = 0.048) following ADT initiation. The QLQ-PR25 revealed a significant decline in sexual functioning (from 59 to 26.9; p < 0.001) and sexual activity (from 27.3 to 12; p = 0.001). Interviews revealed a significant rise in the number of patients reporting depressed mood. Interviews also highlighted a worsening in body image perception and sexuality, increased feelings of dependence, and challenges in the social and relational spheres.

Conclusions: ADT significantly impacts various aspects of quality of life in men with prostate cancer, particularly physical functioning, fatigue, sexual function, body image, and emotional well-being. These results underscore the critical importance of a comprehensive, patient-centered approach that addresses both the physical and psychosocial aspects of care.

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来源期刊

Oncology and Therapy ONCOLOGY-

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Now indexed in PubMed Aims and Scope Oncology and Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Oncology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. 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