在晚期鼻咽癌化疗期间使用他汀类药物

IF 14.8 2区 医学 Q1 ONCOLOGY
Jung-Min Yu, Chia-Lun Chang, Kuan-Chou Lin, Wan-Ming Chen, Ben-Chang Shia, Szu-Yuan Wu
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引用次数: 0

摘要

研究背景本研究旨在评估他汀类药物的使用对接受标准同期化放疗(CCRT)的晚期鼻咽癌患者的总生存期(OS)和鼻咽癌特异性生存期的影响:这项倾向得分匹配队列研究使用了台湾癌症登记数据库和国民健康保险研究数据库的数据,研究在CCRT期间使用他汀类药物对OS和鼻咽癌特异性生存率的影响:结果:CCRT期间使用他汀类药物对OS和NPC特异性生存有显著的独立预后价值。他汀类药物组与非他汀类药物组相比,调整后的全因死亡率危险比为0.48(95% CI,0.34-0.68;PC结论:本研究表明,在鼻咽癌 CCRT 期间使用他汀类药物可能会提高 OS 和鼻咽癌特异性生存率。我们的研究结果表明,洛伐他汀、阿托伐他汀和洛伐他汀可能对接受 CCRT 的鼻咽癌患者的生存有益。观察到的剂量-反应关系强调了更多地使用他汀类药物在降低鼻咽癌特异性死亡率方面的潜在重要性,但要建立明确的因果关系还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Statin Use During Concurrent Chemoradiotherapy for Advanced Nasopharyngeal Cancer.

Background: The objective of this study was to assess the impact of statin use on overall survival (OS) and nasopharyngeal cancer (NPC)-specific survival in patients with advanced NPC who underwent standard concurrent chemoradiotherapy (CCRT).

Patients and methods: This propensity score matched cohort study used data from the Taiwan Cancer Registry Database and National Health Insurance Research Database to examine the impact of statin use during CCRT on both OS and NPC-specific survival.

Results: Statin use during CCRT demonstrated significant and independent prognostic value for both OS and NPC-specific survival. The adjusted hazard ratio for all-cause mortality in the statin group compared with the nonstatin group was 0.48 (95% CI, 0.34-0.68; P<.0001). Similarly, the adjusted hazard ratio for NPC-specific mortality in the statin group compared with the nonstatin group was 0.43 (95% CI, 0.29-0.65; P<.0001). Rosuvastatin, atorvastatin, and lovastatin demonstrated significant efficacy in improving NPC-specific survival outcomes. Moreover, our findings indicate a dose-response relationship, with higher cumulative defined daily doses and greater daily intensity of statin use associated with reduced mortality.

Conclusions: This study suggests an association between statin use during the CCRT period for NPC and potential enhancements in both OS and NPC-specific survival. Our findings indicate a possible survival benefit of rosuvastatin, atorvastatin, and lovastatin for patients with NPC undergoing CCRT. The observed dose-response relationship underscores the potential importance of higher statin use in mitigating NPC-specific mortality, but further research is needed to establish a definitive causal relationship.

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来源期刊
CiteScore
20.20
自引率
0.00%
发文量
388
审稿时长
4-8 weeks
期刊介绍: JNCCN—Journal of the National Comprehensive Cancer Network is a peer-reviewed medical journal read by over 25,000 oncologists and cancer care professionals nationwide. This indexed publication delivers the latest insights into best clinical practices, oncology health services research, and translational medicine. Notably, JNCCN provides updates on the NCCN Clinical Practice Guidelines in Oncology® (NCCN Guidelines®), review articles elaborating on guideline recommendations, health services research, and case reports that spotlight molecular insights in patient care. Guided by its vision, JNCCN seeks to advance the mission of NCCN by serving as the primary resource for information on NCCN Guidelines®, innovation in translational medicine, and scientific studies related to oncology health services research. This encompasses quality care and value, bioethics, comparative and cost effectiveness, public policy, and interventional research on supportive care and survivorship. JNCCN boasts indexing by prominent databases such as MEDLINE/PubMed, Chemical Abstracts, Embase, EmCare, and Scopus, reinforcing its standing as a reputable source for comprehensive information in the field of oncology.
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