通过皮下渗透泵输送干细胞再生化合物

Q4 Biochemistry, Genetics and Molecular Biology

Methods in molecular biology Pub Date : 2024-11-10 DOI:10.1007/7651_2024_573

Sen Zhang, Sandra Pinho

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引用次数: 0

摘要

衰老被广泛认为是哺乳动物一生中不可逆转的生理过程，其特点是组织功能退化和疾病发病率增加。哺乳动物衰老的标志之一是组织再生能力下降，这主要归因于组织特异性干细胞功能的衰退。近年来，人们广泛探索了各种旨在通过给药系统使干细胞恢复活力的策略。在这里，我们描述了一种利用渗透泵皮下植入长期、可控、全身性给药的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Delivery of Stem Cell-Rejuvenating Compounds via Subcutaneous Osmotic Pumps.

Aging is widely regarded as an irreversible physiological process throughout the mammalian lifespan, characterized by functional tissue deterioration and increased disease incidence. One hallmark of mammalian aging is reduced tissue regeneration, primarily attributed to the declining function of tissue-specific stem cells. In recent years, various strategies aimed at rejuvenating stem cells through drug-delivery systems have been extensively explored. Here we describe a method for the long-term, controlled, systemic delivery of drugs using subcutaneous implantations of osmotic pumps.

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来源期刊

Methods in molecular biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.00

自引率

0.00%

发文量

3536

期刊介绍： For over 20 years, biological scientists have come to rely on the research protocols and methodologies in the critically acclaimed Methods in Molecular Biology series. The series was the first to introduce the step-by-step protocols approach that has become the standard in all biomedical protocol publishing. Each protocol is provided in readily-reproducible step-by-step fashion, opening with an introductory overview, a list of the materials and reagents needed to complete the experiment, and followed by a detailed procedure that is supported with a helpful notes section offering tips and tricks of the trade as well as troubleshooting advice.