自身免疫性疾病中的调节性 B 细胞：见解和治疗潜力。

IF 7.9 1区医学 Q1 IMMUNOLOGY

Journal of autoimmunity Pub Date : 2024-11-08 DOI:10.1016/j.jaut.2024.103326

Qin-Yi Su , Zhong-Qing Jiang , Xuan-Yi Song , Sheng-Xiao Zhang

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引用次数: 0

摘要

自身免疫性疾病的特征是人体免疫系统攻击自身细胞，如系统性红斑狼疮（SLE）、类风湿性关节炎（RA）和多发性硬化症（MS）。最近的研究显示，调节性 B 细胞（Bregs）在维持外周耐受性和控制顽固性自身免疫性疾病（ADs）方面发挥着重要作用，在治疗 ADs 方面具有巨大潜力。这篇综述综述了ADs靶向疗法的最新进展，特别强调了与Bregs相关的亚群、表型标记和信号通路。在对这些要素进行研究之后，讨论将转向基于 Breg 的创新性治疗方法，以治疗多发性硬化症。

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Regulatory B cells in autoimmune diseases: Insights and therapeutic potential

Autoimmune diseases are characterized by the body's immune system attacking its own cells, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). In recent studies, regulatory B cells (Bregs), which play a vital role in maintaining peripheral tolerance and controlling persistent autoimmune diseases (ADs), have shown great potential in treating ADs. This review synthesizes the latest advancements in targeted therapies for ADs, with a particular emphasis on the subgroups, phenotypic markers, and signal pathways associated with Bregs. Following an examination of these elements, the discussion pivots to innovative Breg-based therapeutic approaches for the management of ADs.

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来源期刊

Journal of autoimmunity 医学-免疫学

CiteScore

27.90

自引率

1.60%

发文量

117

审稿时长

17 days

期刊介绍： The Journal of Autoimmunity serves as the primary publication for research on various facets of autoimmunity. These include topics such as the mechanism of self-recognition, regulation of autoimmune responses, experimental autoimmune diseases, diagnostic tests for autoantibodies, as well as the epidemiology, pathophysiology, and treatment of autoimmune diseases. While the journal covers a wide range of subjects, it emphasizes papers exploring the genetic, molecular biology, and cellular aspects of the field. The Journal of Translational Autoimmunity, on the other hand, is a subsidiary journal of the Journal of Autoimmunity. It focuses specifically on translating scientific discoveries in autoimmunity into clinical applications and practical solutions. By highlighting research that bridges the gap between basic science and clinical practice, the Journal of Translational Autoimmunity aims to advance the understanding and treatment of autoimmune diseases.