美国新诊断多发性骨髓瘤患者接受三联和四联疗法的实际情况分析。

IF 2.7 4区医学 Q2 HEMATOLOGY

Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-10-09 DOI:10.1016/j.clml.2024.10.006

Ludovic Saba, Chieh-Lin Fu, Hong Liang, Chakra P Chaulagain

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引用次数: 0

摘要

背景：在美国，多发性骨髓瘤（MM）患者接受三联和四联疗法的机会不均等仍是一项挑战。我们旨在利用 NCDB 数据调查影响治疗机会的人口和社会经济因素：我们对 2004 年至 2020 年间确诊的 101,867 名 MM 患者进行了分析。采用多项式逻辑回归和多变量考克斯回归分别评估影响治疗机会和生存率的因素：与白人患者相比，黑人患者接受三联和四联治疗的几率明显较低。保险状况和家庭收入等社会经济因素也会影响治疗机会。然而，尽管在获得治疗方面存在差异，但黑人和西班牙裔患者的生存率更高：结论：在美国，与种族、社会经济和保险相关的差异在获得最佳 MM 治疗方面依然存在。解决这些障碍对于确保公平的医疗服务和改善患者预后至关重要。

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A Real-World Analysis on Access to Triplet and Quadruplet Therapy in Newly Diagnosed Multiple Myeloma Patients in the United States.

Background: Disparities in access to triplet and quadruplet therapy for multiple myeloma (MM) patients remain a challenge in the United States. We aimed to investigate demographic and socioeconomic factors influencing treatment access using NCDB data.

Patients and methods: We analyzed 101,867 MM patients diagnosed between 2004 and 2020. Multinomial logistic regression and multivariable cox regression were employed to assess factors influencing treatment access and survival, respectively.

Results: Black patients exhibited significantly lower odds of receiving triplet and quadruplet therapy compared to White patients. Socioeconomic factors such as insurance status and household income also influenced treatment access. However, Black and Hispanic patients demonstrated better survival outcomes despite disparities in access.

Conclusion: Racial, socioeconomic, and insurance-related disparities persist in access to optimal MM therapy in the USA. Addressing these barriers is essential for ensuring equitable healthcare delivery and improving patient outcomes.

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来源期刊

Clinical Lymphoma, Myeloma & Leukemia ONCOLOGY-HEMATOLOGY

CiteScore

2.70

自引率

3.70%

发文量

1606

审稿时长

26 days

期刊介绍： Clinical Lymphoma, Myeloma & Leukemia is a peer-reviewed monthly journal that publishes original articles describing various aspects of clinical and translational research of lymphoma, myeloma and leukemia. Clinical Lymphoma, Myeloma & Leukemia is devoted to articles on detection, diagnosis, prevention, and treatment of lymphoma, myeloma, leukemia and related disorders including macroglobulinemia, amyloidosis, and plasma-cell dyscrasias. The main emphasis is on recent scientific developments in all areas related to lymphoma, myeloma and leukemia. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.