TCF3::ZNF384融合的混合型白血病，表现为孤立的纵隔肿块。

IF 3 3区医学 Q2 HEMATOLOGY

Annals of Hematology Pub Date : 2024-11-12 DOI:10.1007/s00277-024-06042-x

Wing-Yan Au, Chit Chow, Ka-Fai To, Edmond S K Ma, Eugene C L Yeung, Wai-Lun Yip, Helen M H Chan, Harinder Gill

{"title":"TCF3::ZNF384融合的混合型白血病，表现为孤立的纵隔肿块。","authors":"Wing-Yan Au, Chit Chow, Ka-Fai To, Edmond S K Ma, Eugene C L Yeung, Wai-Lun Yip, Helen M H Chan, Harinder Gill","doi":"10.1007/s00277-024-06042-x","DOIUrl":null,"url":null,"abstract":"Acute leukemia with TCF3::ZNF384 is a distinct type of acute leukemia that present most commonly as B-acute lymphoblastic leukemia or mixed-phenotype acute leukemia (B/myeloid). We report the first case of TCF3::ZNF384 mixed-phenotype leukemia presenting as isolated extramedullary disease in the mediastinum. Diagnosis using RNA-sequencing and whole genome sequencing on the primary issue is illustrated.","PeriodicalId":8068,"journal":{"name":"Annals of Hematology","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mixed-phenotype leukemia with TCF3::ZNF384 fusion presenting as an isolated mediastinal mass.\",\"authors\":\"Wing-Yan Au, Chit Chow, Ka-Fai To, Edmond S K Ma, Eugene C L Yeung, Wai-Lun Yip, Helen M H Chan, Harinder Gill\",\"doi\":\"10.1007/s00277-024-06042-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute leukemia with TCF3::ZNF384 is a distinct type of acute leukemia that present most commonly as B-acute lymphoblastic leukemia or mixed-phenotype acute leukemia (B/myeloid). We report the first case of TCF3::ZNF384 mixed-phenotype leukemia presenting as isolated extramedullary disease in the mediastinum. Diagnosis using RNA-sequencing and whole genome sequencing on the primary issue is illustrated.\",\"PeriodicalId\":8068,\"journal\":{\"name\":\"Annals of Hematology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Hematology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00277-024-06042-x\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00277-024-06042-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

TCF3::ZNF384急性白血病是一种独特的急性白血病类型，最常见的表现为B型急性淋巴细胞白血病或混合表型急性白血病（B型/髓系）。我们报告了首例表现为纵隔孤立性髓外疾病的 TCF3::ZNF384 混合表型白血病病例。该病例利用 RNA 测序和全基因组测序对主要问题进行了诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mixed-phenotype leukemia with TCF3::ZNF384 fusion presenting as an isolated mediastinal mass.

Acute leukemia with TCF3::ZNF384 is a distinct type of acute leukemia that present most commonly as B-acute lymphoblastic leukemia or mixed-phenotype acute leukemia (B/myeloid). We report the first case of TCF3::ZNF384 mixed-phenotype leukemia presenting as isolated extramedullary disease in the mediastinum. Diagnosis using RNA-sequencing and whole genome sequencing on the primary issue is illustrated.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annals of Hematology 医学-血液学

CiteScore

5.60

自引率

2.90%

发文量

304

审稿时长

2 months

期刊介绍： Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.