带有炔基的五甲基氰基染料，可作为与靶向分子共轭的透视结构。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-10 DOI:10.1016/j.bmcl.2024.130025

Anastasiia A Uspenskaia, Irina A Doroshenko, Kseniia A Popovicheva, Nazar V Shmychkov, Ekaterina V Pryakhina, Radik R Shafikov, Dmitrii A Skvortsov, Mikhail K Beklemishev, Olga V Zaborova, Tatiana A Podrugina, Aleksei E Machulkin, Elena K Beloglazkina

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引用次数: 0

摘要

我们报告了一种适合叠氮-炔环化反应的改性羰花青基不对称荧光染料，它具有良好的光化学特性（Φfl = 0,49）。新荧光团的一个应用实例是与针对前列腺特异性膜抗原（PSMA）的配体共轭，PSMA 是广泛使用的前列腺癌标志物之一。

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Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety.

We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φ_fl = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers.

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来源期刊

Bioorganic & Medicinal Chemistry Letters 医学-医药化学

CiteScore

5.70

自引率

3.70%

发文量

463

审稿时长

27 days

期刊介绍： Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes articles in the form of communications reporting experimental or theoretical results of special interest, and strives to provide maximum dissemination to a large, international audience.