针对白血病中的 RNA 修饰：外显子转录组药物是新宠。

IF 5.1 2区医学 Q1 HEMATOLOGY

British Journal of Haematology Pub Date : 2024-11-10 DOI:10.1111/bjh.19894

Manel Esteller

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引用次数: 0

摘要

在这篇文章中，Chen 等人发现，在急性髓性白血病中，转移 RNA 的化学修饰及其相应的 RNA 修饰酶会减少。这些发现进一步证实了表转录组异常在血液恶性肿瘤中的作用。相关评论Chen等人.羟基丁甙tRNA修饰作为白血病的疾病进展指标和治疗靶点.Doi: 10.1111/bjh.19873.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting RNA modifications in leukaemia: Epitranscriptomic drugs are the new kids on the block.

In this article, Chen et al. show that a chemical modification of transfer RNA, along its corresponding RNA modifier enzyme, is diminished in acute myeloid leukaemia. These findings further support the role of an aberrant epitranscriptome in haematological malignancies. Commentary on: Chen et al. Hydroxy-wybutosine tRNA modifications as indicators of disease progression and therapeutic targets in leukemia. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19873.

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.