葡萄糖依赖性胰岛素促肽的真正性质是什么？内源性与药物性。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-11-14 DOI:10.1111/jdi.14357

Yuji Yamazaki, Yutaka Seino

引用次数: 0

摘要

GIP 是一种多方面的激素，其在新陈代谢中的作用高度依赖于环境。药理 GIP 受体激活可促进减肥并改善胰岛素敏感性，这与内源性 GIP 的致脂和胰岛素抵抗作用形成鲜明对比。然而，目前仍不清楚这些作用是仅仅放大了内源性 GIP 的作用，还是代表了不同的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Which is the real nature of glucose-dependent insulinotropic peptide?: Endogenous vs pharmacological.

GIP is a multifaceted hormone whose role in metabolism is highly context-dependent. Pharmacological GIP receptor activation promotes weight loss and improves insulin sensitivity, contrasting sharply with the lipogenic and insulin-resistant effects of endogenous GIP. However, it remains unclear whether these effects simply amplify endogenous GIP's actions or represent distinct mechanisms.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).