距离解开胰高血糖素样肽-1 受体激动剂的抗炎作用之谜又近了一步。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-11-13 DOI:10.1111/jdi.14346

Hirotaka Watada

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引用次数: 0

摘要

胰高血糖素样肽-1（GLP-1）受体激动剂是一种抗糖尿病药物，对动脉粥样硬化的进展具有抑制作用，人们一直认为其抗炎作用与该药物的抗炎作用有关，但具体机制尚不清楚。最近，Ben Nasr 及其同事提出了易于理解的 GLP-1 受体激动剂抗炎作用机制。他们发现一些正常 T 细胞的细胞膜上表达 GLP-1 受体，并证明 GLP-1 对 T 细胞功能有抑制作用。

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One step closer to solving the mystery of the anti-inflammatory effects of glucagon-like peptide-1 receptor agonists.

Glucagon-like peptide-1 (GLP-1) receptor agonists are antidiabetic drugs that possess a suppressive effect on the progression of atherosclerosis, and it has been thought that their anti-inflammatory effect is involved in their effect, but the detailed mechanism was unknown. Recently, Ben Nasr and colleagues have proposed easily understood mechanism for the anti-inflammatory effect of GLP-1 receptor agonists. They discovered that some normal T cells express GLP-1 receptors on their cell membranes and showed that GLP-1 has an inhibitory effect on T-cell function.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).