Ricardo Lorenzoni, Samuel Davies, Leticia Malgarim Cordenonsi, Isabel Roggia, José Alcides da Silva Viçosa, Nathana Jamille Mezzomo, Amanda Lima de Oliveira, Guilherme Machado do Carmo, Graciela Vitalis, Patrícia Gomes, Renata Platcheck Raffin, Oswaldo Luiz Alves, Rodrigo De Almeida Vaucher, Virginia Cielo Rech
{"title":"含有辛伐他汀的脂核纳米胶囊不会影响大鼠的生化和血液学毒性指标。","authors":"Ricardo Lorenzoni, Samuel Davies, Leticia Malgarim Cordenonsi, Isabel Roggia, José Alcides da Silva Viçosa, Nathana Jamille Mezzomo, Amanda Lima de Oliveira, Guilherme Machado do Carmo, Graciela Vitalis, Patrícia Gomes, Renata Platcheck Raffin, Oswaldo Luiz Alves, Rodrigo De Almeida Vaucher, Virginia Cielo Rech","doi":"10.1093/toxres/tfae189","DOIUrl":null,"url":null,"abstract":"<p><p>Our research group previously studied the effectiveness of lipid-core nanocapsules (LNC) containing simvastatin (SV-LNC) in treating cognitive impairment in rats. While our results were promising, we needed to evaluate the potential toxicity of the nanoparticles themselves. This study aimed to compare the biochemical and hematological parameters of adult Wistar rats receiving LNC or SV-LNC to those receiving low doses of simvastatin crystals dispersed in a saline solution over 45 days. We discovered that LNC and SV-LNC, which are both nanometers in size with low polydispersity index, negative zeta potential, and high SV encapsulation efficacy, were not more toxic than SV crystals based on various biochemical markers of hepatic, pancreatic, renal, mineral, bony, alkaline phosphatase, glucose, and uric acid damage. Furthermore, LNC exhibited no toxicity for hematological parameters, including red and white blood cell counts. Based on this animal model of toxicological study, our findings suggest that long-term administration of LNC is a safe and promising nanocarrier.</p>","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae189"},"PeriodicalIF":2.2000,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557222/pdf/","citationCount":"0","resultStr":"{\"title\":\"Lipid-core nanocapsules containing simvastatin do not affect the biochemical and hematological indicators of toxicity in rats.\",\"authors\":\"Ricardo Lorenzoni, Samuel Davies, Leticia Malgarim Cordenonsi, Isabel Roggia, José Alcides da Silva Viçosa, Nathana Jamille Mezzomo, Amanda Lima de Oliveira, Guilherme Machado do Carmo, Graciela Vitalis, Patrícia Gomes, Renata Platcheck Raffin, Oswaldo Luiz Alves, Rodrigo De Almeida Vaucher, Virginia Cielo Rech\",\"doi\":\"10.1093/toxres/tfae189\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Our research group previously studied the effectiveness of lipid-core nanocapsules (LNC) containing simvastatin (SV-LNC) in treating cognitive impairment in rats. While our results were promising, we needed to evaluate the potential toxicity of the nanoparticles themselves. This study aimed to compare the biochemical and hematological parameters of adult Wistar rats receiving LNC or SV-LNC to those receiving low doses of simvastatin crystals dispersed in a saline solution over 45 days. We discovered that LNC and SV-LNC, which are both nanometers in size with low polydispersity index, negative zeta potential, and high SV encapsulation efficacy, were not more toxic than SV crystals based on various biochemical markers of hepatic, pancreatic, renal, mineral, bony, alkaline phosphatase, glucose, and uric acid damage. Furthermore, LNC exhibited no toxicity for hematological parameters, including red and white blood cell counts. Based on this animal model of toxicological study, our findings suggest that long-term administration of LNC is a safe and promising nanocarrier.</p>\",\"PeriodicalId\":105,\"journal\":{\"name\":\"Toxicology Research\",\"volume\":\"13 6\",\"pages\":\"tfae189\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557222/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/toxres/tfae189\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/toxres/tfae189","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Lipid-core nanocapsules containing simvastatin do not affect the biochemical and hematological indicators of toxicity in rats.
Our research group previously studied the effectiveness of lipid-core nanocapsules (LNC) containing simvastatin (SV-LNC) in treating cognitive impairment in rats. While our results were promising, we needed to evaluate the potential toxicity of the nanoparticles themselves. This study aimed to compare the biochemical and hematological parameters of adult Wistar rats receiving LNC or SV-LNC to those receiving low doses of simvastatin crystals dispersed in a saline solution over 45 days. We discovered that LNC and SV-LNC, which are both nanometers in size with low polydispersity index, negative zeta potential, and high SV encapsulation efficacy, were not more toxic than SV crystals based on various biochemical markers of hepatic, pancreatic, renal, mineral, bony, alkaline phosphatase, glucose, and uric acid damage. Furthermore, LNC exhibited no toxicity for hematological parameters, including red and white blood cell counts. Based on this animal model of toxicological study, our findings suggest that long-term administration of LNC is a safe and promising nanocarrier.
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