褪黑素烟雾剂含有潜在污染物并改变了人类支气管上皮转录组。

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-11-11 DOI:10.1021/acs.chemrestox.4c00295

Kevin D Schichlein, Hye-Young H Kim, Charlotte A Love, Tara N Guhr Lee, Charles R Esther, Ned A Porter, Meghan E Rebuli, Brandie M Ehrmann, Phillip W Clapp, Ilona Jaspers

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引用次数: 0

摘要

褪黑素吸入产品因其比口服褪黑素补充剂吸收更快而受到青少年的欢迎。在这里，我们阐明了人类支气管上皮细胞（hBECs）对吸入气溶胶中高浓度褪黑素的反应，研究了体外hBECs对褪黑素的吸收，并描述了三种市售褪黑素吸入剂的化学成分。暴露于褪黑素气溶胶会减少趋化因子的分泌，并产生免疫抑制基因表达特征。所测试的装置含有潜在的污染物，包括药品和工业化学品。需要对褪黑素吸食器进行进一步调查，以确定其局部和全身毒性。

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Melatonin Vapes Contain Potential Contaminants and Alter the Human Bronchial Epithelial Transcriptome.

Melatonin vaping products, touted for their faster absorption than oral melatonin supplements, have been gaining popularity among adolescents as sleep aid. Here, we elucidated the response of human bronchial epithelial cells (hBECs) to high levels of melatonin from vaped aerosols, investigated the uptake of melatonin by hBECs in vitro, and characterized the chemical composition of three commercially available melatonin vapes. Melatonin vape exposure decreased the secretion of chemokines and produced an immunosuppressive gene expression signature. The tested devices contained potential contaminants, including pharmaceuticals and industrial chemicals. Further investigation is needed for melatonin vapes to determine their local and systemic toxicity.

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.