小于 2 厘米的早期周围非小细胞肺癌的叶下或叶状切除术：随机对照试验的荟萃分析。

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2024-11-06 DOI:10.1016/j.amjsurg.2024.116069

Lei Wang, Jianming Zhou, Shengjie Jing, Bin Liu, Jin Fang, Tao Xue

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引用次数: 0

摘要

研究目的我们的研究旨在探讨在小于 2 厘米的早期非小细胞肺癌中，叶下切除术是否不优于叶状切除术：这是一项随机对照试验的荟萃分析。检索的数据库包括 PubMed、Web of Science、EMBASE 和 Cochrane Central Register，截止日期为 2023 年 6 月 3 日。主要结果为5年生存率，次要结果为5年无病生存率、癌症相关死亡率、复发率、术后肺功能和围手术期事件：共有 5 项研究纳入了 2035 名患者。结果：共纳入了 5 项研究，2035 名患者。研究发现，在 5 年生存率、5 年无病生存率和癌症相关死亡率方面，叶下切除术并不优于叶上切除术。然而，叶下切除术的复发率较高，术后肺功能下降较少：结论：就生存率而言，叶下切除术并不比肺叶切除术差，而且术后肺功能更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sublobar or lobar resection in early-stage peripheral non-small cell lung cancer less than 2cm: A meta-analysis for randomized controlled trials

Objective

The aim of our study was to investigate whether sublobar resection is non-inferior to lobar resection in early-stage non-small cell lung cancer less than 2 cm.

Methods

This is a meta-analysis for randomized controlled trials. Databases including PubMed, Web of Science, EMBASE and Cochrane Central Register were searched up to June 3, 2023. The primary outcome was 5-year survival, and the secondary outcomes were 5-year disease-free survival, cancer-related mortality, recurrence rate, postoperative lung function and perioperative events.

Results

A total of 5 studies enrolling 2035 patients were included. Sublobar resection was found to be non-inferior to lobar resection concerning the 5-year survival rate, 5-year disease-free survival rate and cancer-related mortality. However, sublobar resection was associated with higher recurrence rate and less reduction of postoperative lung function.

Conclusions

Sublobar resection was non-inferior to lobar resection in terms of survival outcomes and was associated with better postoperative lung function.

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.