寄生嗜血杆菌 ER-6P 株（血清 15 型）和长崎株（血清 5 型）磷脂糖的化学酶合成

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-10-25 DOI:10.1021/acs.orglett.4c0366510.1021/acs.orglett.4c03665

Xinhao Zhu, Wenlong Yao*, Na Sun, Mei Chen, Hui Xia, Chang-Cheng Liu*, Yugen Zhu* and Hongzhi Cao*,

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引用次数: 0

摘要

在本文中，我们介绍了一种化学酶法和以多样性为导向的方法，首次合成了寄生嗜血杆菌 15 号血清和 5 号血清的荚膜多糖的八糖重复单元。该合成方法的特点是高效的半乳糖或 N-乙酰半乳糖胺构建模块的酶组装、α-型 H-膦酸盐的高度立体选择性化学构建以及稀有糖供体的β-立体特异性 1,3-糖基化反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemoenzymatic Synthesis of Phosphosaccharides from Haemophilus parasuis Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5)

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Chemoenzymatic Synthesis of Phosphosaccharides from Haemophilus parasuis Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5)

Herein, we describe a chemoenzymatic and diversity-oriented approach for the first syntheses of octasaccharide repeating units of the capsular polysaccharides of Haemophilus parasuis serovar 15 and serovar 5. The synthetic method features efficient enzymatic assembly of sialyl galactose or N-acetyl-galactosamine building blocks, highly stereoselective chemical construction of α-type H-phosphonate, and the β-stereospecific 1,3-glycosylation reaction of a rare sugar donor.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.