Nousheen Iqbal, Atiqa Amirali, Ghulam Ullah Lail, Maria Ali Khan, Rabia Sial, Muhammad Irfan
{"title":"胃食管反流病与哮喘控制和生活质量的相关性：一项来自中低收入国家的横断面研究。","authors":"Nousheen Iqbal, Atiqa Amirali, Ghulam Ullah Lail, Maria Ali Khan, Rabia Sial, Muhammad Irfan","doi":"10.1177/17534666241297879","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastro-esophageal reflux disease (GERD) is a chronic disease that coexists with asthma and is often responsible for repeated exacerbations, as well as has a negative impact on the quality of life (QoL). However, from our continent, there is limited data available on the exact prevalence of GERD in asthma and its association with asthma control and QoL.</p><p><strong>Objective: </strong>To determine the prevalence of GERD in asthma and see its association with asthma control and QoL.</p><p><strong>Design: </strong>A prospective, cross-sectional study was conducted over 8 months from September 2020 to April 2021.</p><p><strong>Methods: </strong>Patients with a confirmed diagnosis of asthma aged 18 years and above were recruited from the outpatient department of pulmonology. Patients' GERD score was calculated using the FSSG SCALE (Frequency Scale for Symptoms of GERD) questionnaire and the Asthma Control Test (ACT) was used to determine asthma control. To assess the QoL, the short form of health survey (SF-36) questionnaire was used. Patients were recruited through a convenience sampling technique.</p><p><strong>Results: </strong>A total of 190 patients were enrolled, the mean age was 33.7 ± 13.3 years and 55.8% were female. Prevalence of GERD was (136) 71.6%. According to the ACT score, 81 (42.6%) patients had very poorly controlled asthma (mean GERD score of 13.73 ± 7.66), compared to 59 (31.1%) asthmatic patients who had well-controlled asthma (mean GERD score of 11.97 ± 7.39, <i>p</i> = 0.43). SF-36 questionnaire was used to measure QoL showed GERD patients had statistically lower scores in the following domains of QoL: \"Role Limitations due to Physical Functioning\" (37.78 vs 57.44, <i>p</i> = 0.003), \"Energy/Fatigue\" (47.47 vs 55.07, <i>p</i> = 0.02), and \"Bodily Pain\" (63.40 vs 72.84, <i>p</i> = 0.01).</p><p><strong>Conclusion: </strong>This study showed a high prevalence of GERD among asthmatic patients with a negative impact on QoL but did not demonstrate a statistically significant relationship between GERD and asthma control.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544649/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation of gastro-esophageal reflux disease with asthma control and quality of life: a cross-sectional study from a low-middle income country.\",\"authors\":\"Nousheen Iqbal, Atiqa Amirali, Ghulam Ullah Lail, Maria Ali Khan, Rabia Sial, Muhammad Irfan\",\"doi\":\"10.1177/17534666241297879\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Gastro-esophageal reflux disease (GERD) is a chronic disease that coexists with asthma and is often responsible for repeated exacerbations, as well as has a negative impact on the quality of life (QoL). However, from our continent, there is limited data available on the exact prevalence of GERD in asthma and its association with asthma control and QoL.</p><p><strong>Objective: </strong>To determine the prevalence of GERD in asthma and see its association with asthma control and QoL.</p><p><strong>Design: </strong>A prospective, cross-sectional study was conducted over 8 months from September 2020 to April 2021.</p><p><strong>Methods: </strong>Patients with a confirmed diagnosis of asthma aged 18 years and above were recruited from the outpatient department of pulmonology. Patients' GERD score was calculated using the FSSG SCALE (Frequency Scale for Symptoms of GERD) questionnaire and the Asthma Control Test (ACT) was used to determine asthma control. To assess the QoL, the short form of health survey (SF-36) questionnaire was used. Patients were recruited through a convenience sampling technique.</p><p><strong>Results: </strong>A total of 190 patients were enrolled, the mean age was 33.7 ± 13.3 years and 55.8% were female. Prevalence of GERD was (136) 71.6%. According to the ACT score, 81 (42.6%) patients had very poorly controlled asthma (mean GERD score of 13.73 ± 7.66), compared to 59 (31.1%) asthmatic patients who had well-controlled asthma (mean GERD score of 11.97 ± 7.39, <i>p</i> = 0.43). 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引用次数: 0
摘要
背景：胃食管反流病（GERD胃食管反流病（GERD）是一种与哮喘并存的慢性疾病，经常导致哮喘反复加重，并对患者的生活质量（QoL）产生负面影响。然而，在我们大陆，关于哮喘患者胃食管反流病的确切患病率及其与哮喘控制和 QoL 的关系的数据非常有限：确定哮喘患者胃食管反流病的发病率，并了解其与哮喘控制和 QoL 的关系：2020年9月至2021年4月，进行了为期8个月的前瞻性横断面研究：方法：从肺科门诊部招募 18 岁及以上确诊为哮喘的患者。使用胃食管反流症状频率量表（FSSG SCALE）问卷计算患者的胃食管反流评分，并使用哮喘控制测试（ACT）确定哮喘控制情况。为了评估患者的 QoL，采用了健康调查简表（SF-36）问卷。患者是通过方便抽样技术招募的：结果：共招募了 190 名患者，平均年龄（33.7±13.3）岁，55.8% 为女性。胃食管反流病的患病率为（136）71.6%。根据 ACT 评分，81 名（42.6%）患者的哮喘控制极差（胃食管反流病平均得分为 13.73 ± 7.66），而 59 名（31.1%）哮喘患者的哮喘控制良好（胃食管反流病平均得分为 11.97 ± 7.39，P = 0.43）。SF-36问卷用于测量QoL，结果显示胃食管反流病患者在以下QoL领域的得分较低："身体功能导致的角色限制"（37.78 vs 57.44，p = 0.003）、"能量/疲劳"（47.47 vs 55.07，p = 0.02）和 "身体疼痛"（63.40 vs 72.84，p = 0.01）：这项研究表明，胃食管反流病在哮喘患者中的发病率很高，会对患者的生活质量产生负面影响，但胃食管反流病与哮喘控制之间并没有统计学意义上的显著关系。
Correlation of gastro-esophageal reflux disease with asthma control and quality of life: a cross-sectional study from a low-middle income country.
Background: Gastro-esophageal reflux disease (GERD) is a chronic disease that coexists with asthma and is often responsible for repeated exacerbations, as well as has a negative impact on the quality of life (QoL). However, from our continent, there is limited data available on the exact prevalence of GERD in asthma and its association with asthma control and QoL.
Objective: To determine the prevalence of GERD in asthma and see its association with asthma control and QoL.
Design: A prospective, cross-sectional study was conducted over 8 months from September 2020 to April 2021.
Methods: Patients with a confirmed diagnosis of asthma aged 18 years and above were recruited from the outpatient department of pulmonology. Patients' GERD score was calculated using the FSSG SCALE (Frequency Scale for Symptoms of GERD) questionnaire and the Asthma Control Test (ACT) was used to determine asthma control. To assess the QoL, the short form of health survey (SF-36) questionnaire was used. Patients were recruited through a convenience sampling technique.
Results: A total of 190 patients were enrolled, the mean age was 33.7 ± 13.3 years and 55.8% were female. Prevalence of GERD was (136) 71.6%. According to the ACT score, 81 (42.6%) patients had very poorly controlled asthma (mean GERD score of 13.73 ± 7.66), compared to 59 (31.1%) asthmatic patients who had well-controlled asthma (mean GERD score of 11.97 ± 7.39, p = 0.43). SF-36 questionnaire was used to measure QoL showed GERD patients had statistically lower scores in the following domains of QoL: "Role Limitations due to Physical Functioning" (37.78 vs 57.44, p = 0.003), "Energy/Fatigue" (47.47 vs 55.07, p = 0.02), and "Bodily Pain" (63.40 vs 72.84, p = 0.01).
Conclusion: This study showed a high prevalence of GERD among asthmatic patients with a negative impact on QoL but did not demonstrate a statistically significant relationship between GERD and asthma control.
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