LX9211，缓解糖尿病周围神经痛的后起之秀。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-11-07 DOI:10.1111/jdi.14342

Chia-Chin Lee, Fu-Shun Ko, Fu-Shun Yen, Chii-Min Hwu

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引用次数: 0

摘要

在一项多中心试验中，LX9211 能明显减轻糖尿病周围神经病变（DPN）患者的疼痛，10 毫克剂量在第一周就有明显缓解。虽然高剂量的疗效较差，但头晕和恶心等副作用一般较轻。这些发现凸显了探索黄酮类化合物等药物和天然疗法治疗 DPN 的重要性。

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LX9211, a rising star for relieving of diabetic peripheral neuropathic pain.

In a multicenter trial, LX9211 significantly reduced pain in diabetic peripheral neuropathy (DPN) patients, with the 10 mg dose showing notable relief by the first week. Although the higher dose was less effective, side effects like dizziness and nausea were generally mild. These findings highlight the importance of exploring both pharmaceutical and natural treatments, such as flavonoids, for managing DPN.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).