BeamSplitter - 一种提供放射治疗计划每个控制点剂量的算法

IF 3.3 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Physica Medica-European Journal of Medical Physics Pub Date : 2024-11-06 DOI:10.1016/j.ejmp.2024.104845

Mathieu Gaudreault , Alex Burton , Vanessa Panettieri , Nicholas Hardcastle

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引用次数: 0

摘要

目的商业放射治疗计划系统（TPS）提供三维时间积分计划剂量分布。四维（4D）剂量计算对于减少剂量率对心脏起搏器的影响、全身照射治疗或因时间而异的患者质量保证至关重要。方法使用 Eclipse 脚本应用编程接口（ESAPI，v16，瓦里安医疗系统）进行自动化。比较了本机构 2022 年治疗的 21 名患者的累积剂量分布和参考剂量分布。这些患者的选择涵盖了广泛的调制给药技术和计划复杂性，并以平均叶对开度（ALPO）进行量化。剂量分布与伽马通过率（γPR）进行了比较。此外，还计算了累积剂量与参考剂量指标（立体定向/非立体定向治疗中的计划靶体积（PTV）D99%/D95%、危险器官（OAR）D5cc/D0.03 cc和平均剂量）之间的平均绝对百分比误差（MAPE）。结果ALPO的范围从11.6毫米到77毫米。所有患者的累积剂量分布与参考剂量分布相似（γPR0mm1% > 90%）。在所有病例中，参考剂量和累积剂量指标之间的 MAPE 均低于 1%。累积剂量和测量剂量之间的平均剂量差低于我们临床上可容忍的 3%。结论BeamSplitter 是首个经过验证的算法，可在商用 TPS 中生成放射治疗计划的 4D 剂量计算。

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The BeamSplitter – An algorithm providing the dose per control point of radiation therapy treatment plans

Purpose

Commercial radiation therapy treatment planning systems (TPS) provide the three-dimensional time-integrated planned dose distribution. A four-dimensional (4D) dose calculation is essential to minimise dose-rate effects on pacemaker or in total body irradiation treatment or for time-dependent patient-specific quality assurance. We introduce the BeamSplitter, an algorithm in a commercial TPS generating 4D dose calculation.

Methods

Automation was performed with the Eclipse Scripting Application Programming Interface (ESAPI, v16, Varian Medical System). The accumulated and reference dose distributions of twenty-one patients treated in 2022 at our institution were compared. The patients were selected to cover a broad range of modulated delivery techniques and plan complexity, quantified with the average leaf pair opening (ALPO). The dose distributions were compared with gamma passing rates (γPR). Moreover, the mean absolute percentage error (MAPE) between accumulated and reference dose metrics (planning target volume (PTV) D99% / D95% in stereotactic / non-stereotactic treatment, organs at risk (OAR) D5cc / D0.03 cc, and mean dose) was calculated. Dose accumulation was validated by point dose measurement.

Results

The ALPO ranged from 11.6 mm to 77 mm. The accumulated and reference dose distributions were similar (

{γ P R}_{0 m m}^{1 %}

> 90 % in all patients). The MAPE between reference and accumulated dose metrics was lower than 1 % in all cases. The average dose difference through time between the accumulated and measured dose was lower than our clinical tolerance of 3 %.

Conclusions

The BeamSplitter is the first validated algorithm generating a 4D dose calculation of radiation therapy treatment plans within a commercial TPS.

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来源期刊

Physica Medica-European Journal of Medical Physics 生物-生物物理

CiteScore

6.80

自引率

14.70%

发文量

493

审稿时长

78 days

期刊介绍： Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.