脑源性细胞外囊泡的 microRNA 图谱：在开发精神疾病药效学生物标记物方面迈出充满希望的一步

IF 6.1 2区医学 Q1 CLINICAL NEUROLOGY

European Neuropsychopharmacology Pub Date : 2024-11-06 DOI:10.1016/j.euroneuro.2024.10.002

Mojtaba Oraki Kohshour , Urs Heilbronner , Thorsten Mueller , Moritz Rossner , Sergi Papiol , Thomas G. Schulze

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引用次数: 0

摘要

微小RNA（miRNA）可能会影响药物代谢，有些药物会影响细胞中miRNA的表达。miRNA存在于细胞外囊泡（EV）中，这些EV-miRNA的特征在不同疾病和疾病状态下会发生变化。因此，近年来，EV-miRNA 作为可能的非侵入性生物标记物引起了越来越多的关注。例如，分析血液中脑源EVs的miRNA表达谱可让我们非侵入性地评估miRNA失调，从而了解精神疾病的病理生理学并确定潜在的新预测靶点。我们在PubMed上搜索了所有与精神科药物对EV-miRNA影响相关的研究，并确定了14篇相关文章。综上所述，研究结果表明，某些EV-miRNA可能是精神科药物的靶点，奥氮平等抗精神病药物和氟西汀等抗抑郁药物可能会改变特定EV-miRNA的表达水平。如果这些发现得到证实和复制，可能会将建议的 miRNA 图谱用作药效学生物标志物。然而，关于 EV-miRNA 在精神疾病中的作用及其与神经元基因表达和药物之间的相互作用，仍然存在异质性和不确定性。本微综述总结了精神科药物对 EV-miRNAs 影响的一些研究结果，并阐述了 EV-miRNAs 作为精神疾病药效学生物标记物的潜在作用。

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The microRNA profile of brain-derived extracellular vesicles: A promising step forward in developing pharmacodynamic biomarkers for psychiatric disorders

MicroRNAs (miRNAs) have the potential to affect drug metabolism, and some drugs affect cellular miRNA expression. miRNAs are found inside extracellular vesicles (EVs), and the profile of these EV-miRNAs can change across different diseases and disease states. Consequently, in recent years EV-miRNAs have attracted increasing attention as possible non-invasive biomarkers. For example, analyzing the miRNA expression profile of brain-derived EVs in blood may allow us to non-invasively assess miRNA dysregulation and thus to gain knowledge about the pathophysiology of psychiatric disorders and identify potential new predictive targets. We searched PubMed for all studies related to the effects of psychiatric medications on EV-miRNAs and identified 14 relevant articles. Taken together, findings indicate that certain EV-miRNAs may be targets for psychiatric medications and that antipsychotics such as olanzapine and antidepressants such as fluoxetine may alter the expression levels of particular EV-miRNAs. If confirmed and replicated, these findings may lead to the suggested miRNA profiles being used as pharmacodynamic biomarkers. However, heterogeneities and uncertainties remain regarding the role of EV-miRNAs in psychiatric disorders and their interaction with neuronal gene expression and drugs. This minireview summarizes some of the findings on the effects of psychiatric medications on EV-miRNAs and describes the potential role of EV-miRNAs as pharmacodynamic biomarkers for psychiatric disorders.

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来源期刊

European Neuropsychopharmacology 医学-精神病学

CiteScore

10.30

自引率

5.40%

发文量

730

审稿时长

41 days

期刊介绍： European Neuropsychopharmacology is the official publication of the European College of Neuropsychopharmacology (ECNP). In accordance with the mission of the College, the journal focuses on clinical and basic science contributions that advance our understanding of brain function and human behaviour and enable translation into improved treatments and enhanced public health impact in psychiatry. Recent years have been characterized by exciting advances in basic knowledge and available experimental techniques in neuroscience and genomics. However, clinical translation of these findings has not been as rapid. The journal aims to narrow this gap by promoting findings that are expected to have a major impact on both our understanding of the biological bases of mental disorders and the development and improvement of treatments, ideally paving the way for prevention and recovery.