与帕金森病精神病相关的功能和连接相关性:系统综述。

IF 4.1 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI:10.1093/braincomms/fcae358
Sara Pisani, Brandon Gunasekera, Yining Lu, Miriam Vignando, Dominic Ffytche, Dag Aarsland, K R Chaudhuri, Clive Ballard, Jee-Young Lee, Yu Kyeong Kim, Latha Velayudhan, Sagnik Bhattacharyya
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引用次数: 0

摘要

帕金森病精神病的神经基础至今仍不清楚,相关研究和综述也相对较少。在此,我们采用系统综述的方法,旨在定性地综合使用不同神经影像模式调查帕金森病精神病特异性大脑结构、功能或化学改变的研究证据。我们在 PubMed、Web of Science 和 Embase 数据库中搜索了功能性核磁共振成像(基于任务和静息状态)、弥散张量成像、正电子发射计算机断层扫描和单光子发射计算机断层扫描等研究,并将帕金森病精神病患者与未患精神病的帕金森病患者进行了比较。我们报告了 29 项研究的结果(514 名帕金森病精神病患者,平均年龄 ± SD = 67.92 ± 4.37 岁;51.36% 为男性;853 名帕金森病患者,平均年龄 ± SD = 66.75 ± 4.19 岁;55.81% 为男性)。定性综合结果显示,与未患精神病的帕金森病患者相比,帕金森病精神病患者在基于任务和静息状态的功能磁共振成像研究中普遍存在大脑功能改变的模式。同样,顶叶、颞叶和枕叶区域的白质也出现了异常。全脑和皮层下区域的新陈代谢不足和多巴胺转运体结合减少也有报道。这表明涉及高阶视觉处理和注意力网络的区域发生了广泛的改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional and connectivity correlates associated with Parkinson's disease psychosis: a systematic review.

Neural underpinnings of Parkinson's disease psychosis remain unclear to this day with relatively few studies and reviews available. Using a systematic review approach, here, we aimed to qualitatively synthesize evidence from studies investigating Parkinson's psychosis-specific alterations in brain structure, function or chemistry using different neuroimaging modalities. PubMed, Web of Science and Embase databases were searched for functional MRI (task-based and resting state), diffusion tensor imaging, PET and single-photon emission computed tomography studies comparing Parkinson's disease psychosis patients with Parkinson's patients without psychosis. We report findings from 29 studies (514 Parkinson's psychosis patients, mean age ± SD = 67.92 ± 4.37 years; 51.36% males; 853 Parkinson's patients, mean age ± SD = 66.75 ± 4.19 years; 55.81% males). Qualitative synthesis revealed widespread patterns of altered brain function across task-based and resting-state functional MRI studies in Parkinson's psychosis patients compared with Parkinson's patients without psychosis. Similarly, white matter abnormalities were reported in parietal, temporal and occipital regions. Hypo-metabolism and reduced dopamine transporter binding were also reported whole brain and in sub-cortical areas. This suggests extensive alterations affecting regions involved in high-order visual processing and attentional networks.

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