Srirupa Hari Gopal, Robert Tillman, James D Hammond Ii, Joseph L Hagan, Sharada H Gowda, Nidhy P Varghese, Caraciolo J Fernandes
{"title":"先天性膈疝患者开放动脉导管的时间与预后之间的关系","authors":"Srirupa Hari Gopal, Robert Tillman, James D Hammond Ii, Joseph L Hagan, Sharada H Gowda, Nidhy P Varghese, Caraciolo J Fernandes","doi":"10.1159/000541385","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension, its role on long-term outcomes in CDH has not been investigated. Our objective was to examine associations of the PDA with long-term clinical outcomes in CDH.</p><p><strong>Methods: </strong>A single-center retrospective descriptive study of 122 CDH patients dichotomized by duration with PDA, as ≤14 versus >14 postnatal days (PND) and ≤30 versus >30 PND. Fisher's exact test, Wilcoxon rank-sum test, and multiple linear and logistic regression analyses were used for analyses.</p><p><strong>Results: </strong>In unadjusted and adjusted for CDH severity comparisons, patients with PDA >14 PND and >30 PND had a higher risk of death, longer length of stay, mechanical ventilation duration, and need for tracheostomy, diuretics, and PH medications at discharge.</p><p><strong>Conclusion: </strong>A PDA beyond the newborn period is associated with adverse outcomes in infants with CDH.</p>","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":" ","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia.\",\"authors\":\"Srirupa Hari Gopal, Robert Tillman, James D Hammond Ii, Joseph L Hagan, Sharada H Gowda, Nidhy P Varghese, Caraciolo J Fernandes\",\"doi\":\"10.1159/000541385\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension, its role on long-term outcomes in CDH has not been investigated. Our objective was to examine associations of the PDA with long-term clinical outcomes in CDH.</p><p><strong>Methods: </strong>A single-center retrospective descriptive study of 122 CDH patients dichotomized by duration with PDA, as ≤14 versus >14 postnatal days (PND) and ≤30 versus >30 PND. Fisher's exact test, Wilcoxon rank-sum test, and multiple linear and logistic regression analyses were used for analyses.</p><p><strong>Results: </strong>In unadjusted and adjusted for CDH severity comparisons, patients with PDA >14 PND and >30 PND had a higher risk of death, longer length of stay, mechanical ventilation duration, and need for tracheostomy, diuretics, and PH medications at discharge.</p><p><strong>Conclusion: </strong>A PDA beyond the newborn period is associated with adverse outcomes in infants with CDH.</p>\",\"PeriodicalId\":94152,\"journal\":{\"name\":\"Neonatology\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neonatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000541385\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neonatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000541385","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia.
Introduction: While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension, its role on long-term outcomes in CDH has not been investigated. Our objective was to examine associations of the PDA with long-term clinical outcomes in CDH.
Methods: A single-center retrospective descriptive study of 122 CDH patients dichotomized by duration with PDA, as ≤14 versus >14 postnatal days (PND) and ≤30 versus >30 PND. Fisher's exact test, Wilcoxon rank-sum test, and multiple linear and logistic regression analyses were used for analyses.
Results: In unadjusted and adjusted for CDH severity comparisons, patients with PDA >14 PND and >30 PND had a higher risk of death, longer length of stay, mechanical ventilation duration, and need for tracheostomy, diuretics, and PH medications at discharge.
Conclusion: A PDA beyond the newborn period is associated with adverse outcomes in infants with CDH.
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