中枢神经系统肿瘤 CAR-T 疗法的进展。

IF 9.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarker Research Pub Date : 2024-11-06 DOI:10.1186/s40364-024-00679-6

Delian Zhou, Xiaojian Zhu, Yi Xiao

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引用次数: 0

摘要

嵌合抗原受体T细胞疗法在中枢神经系统肿瘤中的应用已取得显著进展；然而，与在急性淋巴细胞白血病和弥漫大B细胞淋巴瘤等血液系统恶性肿瘤中的成功不同，嵌合抗原受体T细胞疗法在血脑屏障、免疫抑制微环境和抗原异质性等方面仍面临挑战。这篇综述探讨了嵌合抗原受体T细胞疗法在胶质瘤、髓母细胞瘤和中枢神经系统淋巴造血肿瘤中的研究进展，重点关注嵌合抗原受体T细胞靶向EGFRvIII、HER2、B7H3、GD2和CD19等抗原的临床前和临床研究。它综合了当前的研究成果，为未来中枢神经系统肿瘤的嵌合抗原受体T细胞治疗策略提供了有价值的见解，推动了这一治疗模式在这一领域的发展和应用。

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Advances in CAR-T therapy for central nervous system tumors.

The application of chimeric antigen receptor T-cell therapy in central nervous system tumors has significantly advanced; however, challenges pertaining to the blood-brain barrier, immunosuppressive microenvironment, and antigenic heterogeneity continue to be encountered, unlike its success in hematological malignancies such as acute lymphoblastic leukemia and diffuse large B-cell lymphomas. This review examined the research progress of chimeric antigen receptor T-cell therapy in gliomas, medulloblastomas, and lymphohematopoietic tumors of the central nervous system, focusing on chimeric antigen receptor T-cells targeting antigens such as EGFRvIII, HER2, B7H3, GD2, and CD19 in preclinical and clinical studies. It synthesized current research findings to offer valuable insights for future chimeric antigen receptor T-cell therapeutic strategies for central nervous system tumors and advance the development and application of this therapeutic modality in this domain.

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来源期刊

Biomarker Research Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

15.80

自引率

1.80%

发文量

审稿时长

10 weeks

期刊介绍： Biomarker Research, an open-access, peer-reviewed journal, covers all aspects of biomarker investigation. It seeks to publish original discoveries, novel concepts, commentaries, and reviews across various biomedical disciplines. The field of biomarker research has progressed significantly with the rise of personalized medicine and individual health. Biomarkers play a crucial role in drug discovery and development, as well as in disease diagnosis, treatment, prognosis, and prevention, particularly in the genome era.