母体产前炎症与后代青春期皮层形态之间的性别特异性关联：跨越四个出生队列的统一研究。

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2024-11-05 DOI:10.1016/j.bbi.2024.11.010

Anni Niskanen , Aaron Barron , Hatim Azaryah , Martta Kerkelä , Elmo Pulli , Jetro J. Tuulari , Minna Lukkarinen , Linnea Karlsson , Ryan L. Muetzel , Cristina Campoy , Andrés Catena , Henning Tiemeier , Golam M. Khandaker , Hasse Karlsson , Juha Veijola , Lassi Björnholm

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引用次数: 0

摘要

怀孕期间的母体免疫激活（MIA）与后代的精神障碍有关。然而，在普通人群中，母体免疫激活对神经发育（尤其是大脑皮层解剖结构）的影响程度如何，以及不同性别的影响是否存在差异，目前尚不清楚。本研究采用顶点统计法，对来自三个人群队列和一个富含炎症标记物的临床队列的 2635 对母子（5.4-26.5 岁）产前 CRP（一种典型的全身性炎症标记物）与后代皮层厚度、表面积和体积之间的关系进行了研究。在正常生理范围（10 毫克/升）内的母体 CRP 与女性和汇总的性别样本中的区域皮质形态相关。总体而言，在跨越儿童期到成年期的研究中，MIA 与皮质发育的区域性和性别特异性相关。

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Sex-specific associations between maternal prenatal inflammation and offspring cortical morphology in youth: A harmonised study across four birth cohorts

Maternal immune activation (MIA) during pregnancy is implicated in offspring psychiatric disorders. However, it is unknown to what extent MIA affects neurodevelopment, particularly cerebrocortical anatomy, in the general population, and whether effects differ by sex. The current study used vertex-wise statistics to examine the association between maternal prenatal CRP, an archetypal systemic inflammatory marker, and offspring cortical thickness, surface area, and volume, in 2635 mother–child dyads (5.4–26.5 years) from three population-based cohorts, and one clinical cohort enriched for presence of inflammation markers.

Maternal CRP within a normal physiological range (<10 mg/L) exhibited sex-specific quadratic associations with cortical morphological measures in 2 regions in males and 1 region in females at childhood. Elevated (>10 mg/L) CRP was associated with regional cortical morphology in females and in a pooled sample of sexes. Overall, MIA is associated with cortical development in a regional and sex-specific manner in studies spanning childhood to adulthood.

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.