Ti-Mg 与 Et2Zn 催化的 N-苄基-N-(丁-3-烯-1-基)庚-2-炔-1-胺羧锌化反应

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-11-06 DOI:10.1134/S1070428024080049

A. M. Gabdullin, R. N. Kadikova, I. R. Ramazanov

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引用次数: 0

摘要

研究首次表明，N-苄基-N-(丁-3-烯-1-基)庚-2-炔-1-胺与 Et2Zn 的钛-镁催化羧锌化反应涉及 (Z)-1- 苄基-4-甲基-3-亚戊基哌啶的区域和立体选择性生成。研究了溶剂对 Ti-Mg 催化的 N-苄基-N-(丁-3-烯-1-基)庚-2-炔-1-胺杂环化反应的影响。提出了在催化量的 Ti(O-iPr)4 和 EtMgBr 存在下，用 Et2Zn 对 N-高烯丙基取代的丙炔胺进行羧锌化合的机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ti–Mg-Catalyzed Carbozincation of N-Benzyl-N-(but-3-en-1-yl)hept-2-yn-1-amine with Et2Zn

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Ti–Mg-Catalyzed Carbozincation of N-Benzyl-N-(but-3-en-1-yl)hept-2-yn-1-amine with Et2Zn

It has been shown for the first time that the Ti-Mg-catalyzed carbozincation reaction of N-benzyl-N-(but-3-en-1-yl)hept-2-yn-1-amine with Et₂Zn involves the regio- and stereoselective formation of (Z)-1-benzyl-4-methyl-3-pentylidenepiperidine. The effect of the solvent on the Ti-Mg-catalyzed heterocyclization of N-benzyl-N-(but-3-en-1-yl)hept-2-yn-1-amine was studied. A mechanism of the carbozincation of N-homoallyl-substituted propargylamine with Et₂Zn in the presence of catalytic amounts of Ti(O-iPr)₄ and EtMgBr has been proposed.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.