双截断数据和区间截断数据的 Cox 回归模型

IF 1.5 3区数学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computational Statistics & Data Analysis Pub Date : 2024-11-04 DOI:10.1016/j.csda.2024.108090

Pao-sheng Shen

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引用次数: 0

摘要

区间抽样是流行病学研究中使用的一种高效抽样方案。在这种抽样方案下，当故障时间可以精确观测到时，就会产生双截（DT）数据。在实践中，故障时间可能无法被观察到，而只能在时间间隔内记录，这就导致了双重截断和时间间隔删减（DTIC）数据。本文考虑在 Cox 比例危险（PH）模型下对 DTIC 数据进行回归分析，并开发了模型回归参数和基线累积危险函数的条件最大似然估计值（cMLE）。cMLEs 具有一致性和渐近正态性。模拟结果表明，cMLE 在中等规模的样本中表现良好。

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Cox regression model with doubly truncated and interval-censored data

Interval sampling is an efficient sampling scheme used in epidemiological studies. Doubly truncated (DT) data arise under this sampling scheme when the failure time can be observed exactly. In practice, the failure time may not be observed and might be recorded only within time intervals, leading to doubly truncated and interval censored (DTIC) data. This article considers regression analysis of DTIC data under the Cox proportional hazards (PH) model and develops the conditional maximum likelihood estimators (cMLEs) for the regression parameters and baseline cumulative hazard function of models. The cMLEs are shown to be consistent and asymptotically normal. Simulation results indicate that the cMLEs perform well for samples of moderate size.

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来源期刊

Computational Statistics & Data Analysis 数学-计算机：跨学科应用

CiteScore

3.70

自引率

5.60%

发文量

167

审稿时长

60 days

期刊介绍： Computational Statistics and Data Analysis (CSDA), an Official Publication of the network Computational and Methodological Statistics (CMStatistics) and of the International Association for Statistical Computing (IASC), is an international journal dedicated to the dissemination of methodological research and applications in the areas of computational statistics and data analysis. The journal consists of four refereed sections which are divided into the following subject areas: I) Computational Statistics - Manuscripts dealing with: 1) the explicit impact of computers on statistical methodology (e.g., Bayesian computing, bioinformatics,computer graphics, computer intensive inferential methods, data exploration, data mining, expert systems, heuristics, knowledge based systems, machine learning, neural networks, numerical and optimization methods, parallel computing, statistical databases, statistical systems), and 2) the development, evaluation and validation of statistical software and algorithms. Software and algorithms can be submitted with manuscripts and will be stored together with the online article. II) Statistical Methodology for Data Analysis - Manuscripts dealing with novel and original data analytical strategies and methodologies applied in biostatistics (design and analytic methods for clinical trials, epidemiological studies, statistical genetics, or genetic/environmental interactions), chemometrics, classification, data exploration, density estimation, design of experiments, environmetrics, education, image analysis, marketing, model free data exploration, pattern recognition, psychometrics, statistical physics, image processing, robust procedures. [...] III) Special Applications - [...] IV) Annals of Statistical Data Science [...]