BLyS/APRIL 在自身免疫性疾病中的新作用:生物学特征、功能和治疗潜力

IF 7.9 1区 医学 Q1 IMMUNOLOGY
Shi-Zhi Hu , Zhan-Yuan Yuan , Xiao-Xun Zhang , Xiao-Jing Yu , Hai-Yan Ni , Sheng-Jia Sun , Tao Xu , He-Qin Zhan
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引用次数: 0

摘要

自身免疫性疾病(AID)是世界上常见的疾病。有些病例很难治愈,只能延缓疾病的发展。B 淋巴细胞刺激素(BLyS)/增殖诱导配体(APRIL)在 B 细胞平衡、调节先天性和适应性免疫反应中发挥着重要作用。与受体结合后,BLyS/APRIL 主要影响边缘、过渡和成熟 B 细胞的存活和发育。值得注意的是,BLyS/APRIL 的升高可见于许多 AID,如系统性红斑狼疮、类风湿性关节炎、免疫球蛋白 A 肾病等。此外,有证据表明,阻断这两种细胞因子可以控制血清自身抗体的数量,促进 B 淋巴细胞的消耗,抑制 T 细胞和树突状淋巴细胞的活化,减轻炎症应激反应。目前,一些针对 BLyS/APRIL 抑制剂治疗艾滋病的临床研究正在进行中。然而,由于对 BLyS/APRIL 与艾滋病之间关系的了解比较零散,因此有必要对现有数据进行梳理。因此,在这篇综述中,我们描述了BLyS/APRIL在AIDs中的基本生物学特性和功能,总结了相关抑制剂,尤其是靶向BLyS/APRIL的单克隆抗体和重组融合蛋白在AIDs中的潜在临床应用,并概述了有前景的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The emerging role of BLyS/APRIL in autoimmune diseases: Biological characteristics, functions, and therapeutic potential
Autoimmune diseases (AIDs) are common diseases in the world. Some cases are difficult to cure and can only delay the progression of the diseases. The B lymphocyte stimulator (BLyS)/a proliferation-inducing ligand (APRIL) plays an important role in B cell homeostasis, regulation of both innate and adaptive immune responses. After binding to their receptors, BLyS/APRIL primarily affects the survival and development of marginal, transitional, and mature B cells. Of note, elevated BLyS/APRIL is seen in many AIDs, such as systemic lupus erythematosus, rheumatoid arthritis, immunoglobulin A nephropathy, etc. Moreover, there is evidence that blocking these two cytokines can control the number of serum autoantibodies, promote the depletion of B lymphocytes, inhibit the activation of T cells and dendritic lymphocytes, and reduce inflammatory stress. Currently, some clinical studies are underway targeting BLyS/APRIL inhibitors for the treatment of AIDs. However, due to the scattered knowledge on the relationship between BLyS/APRIL and AIDs, it is necessary to sort out the existing data. Therefore, in this review, we describe the basic biological characteristics and functions of BLyS/APRIL in AIDs, summarize the potential clinical applications of related inhibitors, especially monoclonal antibodies and recombinant fusion proteins targeting BLyS/APRIL in AIDs, and also outline promising research directions.
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来源期刊
Journal of autoimmunity
Journal of autoimmunity 医学-免疫学
CiteScore
27.90
自引率
1.60%
发文量
117
审稿时长
17 days
期刊介绍: The Journal of Autoimmunity serves as the primary publication for research on various facets of autoimmunity. These include topics such as the mechanism of self-recognition, regulation of autoimmune responses, experimental autoimmune diseases, diagnostic tests for autoantibodies, as well as the epidemiology, pathophysiology, and treatment of autoimmune diseases. While the journal covers a wide range of subjects, it emphasizes papers exploring the genetic, molecular biology, and cellular aspects of the field. The Journal of Translational Autoimmunity, on the other hand, is a subsidiary journal of the Journal of Autoimmunity. It focuses specifically on translating scientific discoveries in autoimmunity into clinical applications and practical solutions. By highlighting research that bridges the gap between basic science and clinical practice, the Journal of Translational Autoimmunity aims to advance the understanding and treatment of autoimmune diseases.
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