{"title":"免疫球蛋白 A 肾病：综述。","authors":"Sulaiman Aseem, Sijie Zheng","doi":"10.7812/TPP/24.089","DOIUrl":null,"url":null,"abstract":"<p><p>Immunoglobulin A nephropathy is a primary glomerulopathy, with prevalence ranking highest in the Pacific region, followed closely by Europe, but rare in Africa. Although practice patterns likely have contributed to its prevalence, there are genetic and environmental factors that contribute as well. Management has evolved over the past decade, with recent rapid advances in diagnosis, prognosis, and therapies. This review summarizes the history, pathogenesis, and diagnosis of immunoglobulin A nephropathy and also cites relevant clinical trials, latest treatment options, and unanswered questions.</p>","PeriodicalId":23037,"journal":{"name":"The Permanente journal","volume":" ","pages":"87-94"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunoglobulin A Nephropathy: A Review.\",\"authors\":\"Sulaiman Aseem, Sijie Zheng\",\"doi\":\"10.7812/TPP/24.089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Immunoglobulin A nephropathy is a primary glomerulopathy, with prevalence ranking highest in the Pacific region, followed closely by Europe, but rare in Africa. Although practice patterns likely have contributed to its prevalence, there are genetic and environmental factors that contribute as well. Management has evolved over the past decade, with recent rapid advances in diagnosis, prognosis, and therapies. This review summarizes the history, pathogenesis, and diagnosis of immunoglobulin A nephropathy and also cites relevant clinical trials, latest treatment options, and unanswered questions.</p>\",\"PeriodicalId\":23037,\"journal\":{\"name\":\"The Permanente journal\",\"volume\":\" \",\"pages\":\"87-94\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Permanente journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7812/TPP/24.089\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Social Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Permanente journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7812/TPP/24.089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Social Sciences","Score":null,"Total":0}
引用次数: 0
摘要
免疫球蛋白 A 肾病是一种原发性肾小球疾病，在太平洋地区发病率最高，欧洲紧随其后，但在非洲却很少见。虽然实践模式可能是导致其发病率的原因之一，但遗传和环境因素也是原因之一。近十年来，随着诊断、预后和治疗方法的快速进步，对该病的管理也在不断发展。本综述概述了免疫球蛋白 A 肾病的历史、发病机制和诊断，并列举了相关临床试验、最新治疗方案和未决问题。
Immunoglobulin A nephropathy is a primary glomerulopathy, with prevalence ranking highest in the Pacific region, followed closely by Europe, but rare in Africa. Although practice patterns likely have contributed to its prevalence, there are genetic and environmental factors that contribute as well. Management has evolved over the past decade, with recent rapid advances in diagnosis, prognosis, and therapies. This review summarizes the history, pathogenesis, and diagnosis of immunoglobulin A nephropathy and also cites relevant clinical trials, latest treatment options, and unanswered questions.
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