以 LiN(SiMe3)2/KN(SiMe3)2 为介导，基于 Smiles-Rearrangement 方法，从苄基砜和苯甲酸甲酯一步合成二芳基乙炔

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-11-05 DOI:10.1021/acs.orglett.4c03492

Mingyu Jiang, Yan-En Wang, Yuanyun Gu, Ruyuan Ma, Dan Xiong, Patrick J. Walsh, Jianyou Mao

引用次数: 0

摘要

开发了苯甲酸甲酯与 1-(苄磺酰基)-3,5-二(三氟甲基)苯反应一锅合成二苯乙炔的方法。LiN(SiMe3)2 和 KN(SiMe3)2 的结合是促进反应的关键。只需将苯甲酸甲酯、1-(苄磺酰基)-3,5-二(三氟甲基)苯、LiN(SiMe3)2 和 KN(SiMe3)2 结合在一起，就能生成多种二芳基乙炔（28 个实例，产率为 18-70%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Smiles-Rearrangement-Based One-Pot Synthesis of Diarylacetylenes from Benzylic Sulfones and Methyl Benzoates Mediated by LiN(SiMe3)2/KN(SiMe3)2

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Smiles-Rearrangement-Based One-Pot Synthesis of Diarylacetylenes from Benzylic Sulfones and Methyl Benzoates Mediated by LiN(SiMe3)2/KN(SiMe3)2

The one-pot synthesis of diphenylacetylene by the reaction of methyl benzoate with 1-(benzylsulfonyl)-3,5-di(trifluoromethyl)benzene was developed. The combination of LiN(SiMe₃)₂ and KN(SiMe₃)₂ is key to promoting the reaction. Simply combining methyl benzoate, 1-(benzylsulfonyl)-3,5-di(trifluoromethyl)benzene, LiN(SiMe₃)₂, and KN(SiMe₃)₂ can produce a variety of diaryl acetylenes (28 examples, 18–70% yields).

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.