成人高血压患者骨质密度低：荟萃分析

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2024-10-29 DOI:10.1016/j.jor.2024.10.041

Yao Gao , Xiaomei Tian , Guofu Zhang , Jianli Yu , Liwen Zhang

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引用次数: 0

摘要

目的骨质疏松症和高血压是经常并发的疾病，给公众健康带来巨大挑战。一些研究表明，成年高血压患者的骨质密度（BMD）通常较低。然而，报告的结果存在差异。因此，我们进行荟萃分析的主要目的是探讨低 BMD 与成人高血压之间的潜在联系。方法：两位作者通过检索 PubMed、Web of Science、Cochrane 和 Embase，系统地对截至 2024 年 3 月有关 BMD 与高血压关系的现有文献进行了全面回顾。采用随机效应模型估算了置信区间（CI）和几率比（OR）。对异质性、亚组分析、敏感性分析和发表偏倚进行了分析。汇总分析显示，高血压患者发生低 BMD 的危险性明显高于非高血压患者（OR 1.33，95 % CI 1.17-1.53，I2 = 79.9 %，p < 0.01）。亚组分析显示，未接受治疗的高血压组（OR 1.64，95 % CI 0.45-6.02）与接受降压药物治疗的组别（OR 1.32，95 % CI 1.16-1.51）相比，低 BMD 与高血压之间的联系更为明显。结论低 BMD 与成人高血压有关。尽管如此，由于不同研究类型和方法之间存在很大的异质性，这一发现是否受共同风险因素的影响仍不确定。有必要进一步开展广泛的流行病学研究。

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The low bone mass density in adults with hypertension: A meta-analysis

Objectives

Osteoporosis and hypertension are frequently co-occurring disorders which cause significant challenges to the public health. According to some researches, adult persons with hypertension often have low bone mass density (BMD). However, there are discrepancies in the reported results. Thus, the primary objective of our meta-analysis is to explore the potential link between low BMD and hypertension in adults.

Methods

Two authors systematically carried out a comprehensive review of the available literature on the connection of BMD and hypertension by retrieving PubMed, Web of Science, Cochrane and Embase up to March 2024. The confidence intervals (CIs) and odds ratios (ORs) and were estimated utilising the random effect model. Heterogeneity, subgroup analysis, sensibility analyses and publication bias were performed.

Results

13 studies from the 6080 unique records were analyzed. Pooled analysis revealed that the danger of low BMD was significantly elevated in hypertensive patients than in non-hypertension (OR 1.33, 95 % CI 1.17–1.53, I² = 79.9 %, p < 0.01). Subgroup analysis revealed a more pronounced link between low BMD and hypertension in the untreated hypertension group (OR 1.64, 95 % CI 0.45–6.02) as opposed to the cohort receiving antihypertensive medication (OR 1.32, 95 % CI 1.16–1.51). The studies carried out in Europe were consistent with those of studies conducted in Asia and North America.

Conclusions

Low BMD is associated with hypertension in adults. Nevertheless, it remains uncertain whether this finding is influenced by shared risk factors, given the considerable heterogeneity between study types and methodologies. Further extensive epidemiological documents are necessary.

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.