Pd/NHC 顺序催化丙选择性合成平面手性大环

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2024-11-04 DOI:10.1039/D4SC05482B

Gongming Yang, Shangde Liu, Shujie Ji, Xingsen Wu and Jian Wang

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引用次数: 0

摘要

平面手性大环在主客体化学和药物发现中发挥着举足轻重的作用。然而，与合成其他类型的手性化合物相比，平面手性大环的不对称构建仍然是一项艰巨的挑战。在此，我们报告了一种顺序钯和 N-杂环碳烯催化构建平面手性大环的方法。该方案具有板范围和良好的官能团耐受性，可快速组装出具有优异对映选择性的平面手性大环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles†

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Pd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles†

Planar-chiral macrocycles play a pivotal role in host–guest chemistry and drug discovery. However, compared with the synthesis of other types of chiral compounds, the asymmetric construction of planar-chiral macrocycles still remains a forbidding challenge. Herein, we report a sequential palladium and N-heterocyclic carbene catalysis to build planar-chiral macrocycles. This protocol features broad scope and good functional group tolerance, and allows a rapid assembling of planar-chiral macrocycles with excellent enantioselectivities.

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.